Evidence map›Paper›PMID 32792431›Full record

ArticleBMJ open2020

Impact of incremental versus conventional initiation of haemodialysis on residual kidney function: study protocol for a multicentre feasibility randomised controlled trial.

Raja Mohammed Kaja Kamal, Ken Farrington, David Wellsted, Sivakumar Sridharan, Bassam Alchi, James Burton, Andrew Davenport, Enric Vilar

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03418181 (Does Incremental Initiation of Haemodialysis Preserve Native Kidney Function? A Multicentre Feasibility Randomised Controlled Trial), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03418181 nacompletednot on this map

Does Incremental Initiation of Haemodialysis Preserve Native Kidney Function? A Multicentre Feasibility Randomised Controlled Trial

TypeinterventionalSponsorEast and North Hertfordshire NHS TrustRan2018 to 2020Enrolled44ConditionsKidney Failure, DialysisArmsStandard Haemodialysis, Incremental dialysis
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Twice Weekly versus Thrice Weekly Hemodialysis-A Pilot Cross-Over Equivalence Trial.Clinical journal of the American Society of Nephrology : CJASN · 2024
    Article
  5. Incremental dialysis: two complementary views.Clinical kidney journal · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Raja Mohammed Kaja KamalRenal Unit, East and North Hertfordshire NHS Trust, Stevenage, UK.ORCID 0000-0002-5737-5888
Ken FarringtonRenal Unit, East and North Hertfordshire NHS Trust, Stevenage, UK.
David WellstedSchool of Life Sciences, University of Hertfordshire, Hatfield, Hertfordshire, UK.
Sivakumar SridharanRenal Unit, East and North Hertfordshire NHS Trust, Stevenage, UK.
Bassam AlchiRenal Unit, Royal Berkshire NHS Foundation Trust, Reading, Berkshire, UK.
James BurtonRenal Unit, University Hospitals of Leicester NHS Trust, Leicester, Leicestershire, UK.
Andrew DavenportRenal Unit, Royal Free Hospital, London, UK.
Enric VilarRenal Unit, East and North Hertfordshire NHS Trust, Stevenage, UK enric.vilar@nhs.net.
University of Hertfordshire · GBRoyal Berkshire NHS Foundation Trust · GBThe Royal Free Hospital · GBUniversity Hospitals of Leicester NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPreserving residual kidney function (RKF) may be beneficial to patients on haemodialysis (HD) and it has been proposed that commencing dialysis incrementally rather than three times a week may preserve RKF. In Incremental HD, target dose includes a contribution from RKF, which is added to HD dose, allowing individualisation of the HD prescription. We will conduct a feasibility randomised controlled trial (RCT) comparing incremental HD and conventional three times weekly treatments in incident HD patients. The study is designed also to provide pilot data to allow determination of effect size to power a definitive study. METHODS AND ANALYSIS: After screening to ensure native renal urea clearance >3 mL/min/1.73 m ETHICS AND DISSEMINATION: Ethics approval has been granted by Cambridge South Research Ethics Committee, United Kingdom(REC17/EE/0311). Results will be disseminated via peer-reviewed publication. TRIAL REGISTRATION NUMBER: NCT03418181.

Indexed as

Kidney Failure, ChronicRenal DialysisCognitionFeasibility StudiesHumansKidneyMulticenter Studies as TopicRandomized Controlled Trials as TopicUnited Kingdomadult nephrologydialysisend stage renal failure

Identifiers

PMID32792431
PMCPMC7430462
OpenAlexW3049105362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.