ReviewPaediatric respiratory reviews2020
Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19.
Review in Paediatric respiratory reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Efficacy and safety of tofacitinib on COVID-19 patients: A systematic review and meta-analysis.Heliyon · 2024Article
- Use of Continuous Intravenous Anakinra Infusion in Multisystem Inflammatory Syndrome in Children.Case reports in critical care · 2023Article
- Current evidence on the use of anakinra in COVID-19.International immunopharmacology · 2022Review
- An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19).International immunopharmacology · 2022Review
- Factors associated with hospital and intensive care admission in paediatric SARS-CoV-2 infection: a prospective nationwide observational cohort study.European journal of pediatrics · 2022Observational
- Recent research on the application of biologics in the treatment of multisystem inflammatory syndrome in children after SARS-CoV-2 infection.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Acute Vision Loss and Conjunctival Hemorrhage as Telltale Symptoms of PIMS-TS.Global pediatric health · 2022Article
- Algorithm for the diagnosis and management of the multisystem inflammatory syndrome in children associated with COVID-19.International journal of clinical practice · 2021Review
- A fatal toxic shock-like syndrome post COVID-19 infection in a child.Italian journal of pediatrics · 2021Article
- Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges.World journal of gastroenterology · 2021Review
- COVID-19 Pneumomediastinum: Possible Role of Transesophageal Echo in Bedside Percutaneous Bicaval Double-Lumen ECMO Cannulation in Children. A Case Report.Frontiers in pediatrics · 2021Article
- The Challenge of Managing Children With Periodic Fever Syndromes in the Era of COVID-19.Frontiers in pediatrics · 2020Article
- Case Report: Use of Anakinra in Multisystem Inflammatory Syndrome During COVID-19 Pandemic.Frontiers in pediatrics · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid spread of SARS-CoV-2 infection globally coupled with the relatively high case-fatality rate has led to immediate need for therapeutic intervention to prevent and treat COVID-19 disease. There is accumulating evidence that morbidity and mortality in COVID-19 may be exacerbated by a dysregulated host immune response resulting in significant hyperinflammation and cytokine release. The aim of this review is to describe the basis for the immune dysregulation caused by SARS-CoV-2 infection and to examine current investigations into immunomodulatory therapies aimed at targeting the excessive host immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.