Evidence map›Paper›PMID 32792040›Full record

ArticleComparative medicine2020

Evaluation of Topical Lysostaphin as a Novel Treatment for Instrumented Rhesus Macaques (

Christopher E Cheleuitte-Nieves, Leslie L Diaz, Maria Pardos de la Gandara, Alejandra Gonzalez, Winrich A Freiwald, Hermínia M de Lencastre, Alexander Tomasz, Chad W Euler

Open access · greenAbstract read
In one paragraph

Article in Comparative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Association of Primate Veterinarians' Guidelines for the Judicious Use of Antimicrobials.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021
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  6. Time-dependent behavior of theIranian journal of basic medical sciences · 2021
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Christopher E Cheleuitte-NievesTri-Institutional Training Program in Laboratory Animal Medicine and Science, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York; Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and Hospital for Special Surgery, New York, New York;, Email: cheleuic@mskcc.org.
Leslie L DiazComparative Bioscience Center, The Rockefeller University, New York, New York.
Maria Pardos de la GandaraLaboratory of Microbiology & Infectious Diseases, The Rockefeller University, New York, New York; Present address: National Reference Centre for Escherichia coli, Shigella and Salmonella, Enteric Bacterial Pathogens Unit, Institut Pasteur, Paris, France.
Alejandra GonzalezLaboratory of Neural Systems, The Rockefeller University, New York, New York.
Winrich A FreiwaldLaboratory of Neural Systems, The Rockefeller University, New York, New York.
Hermínia M de LencastreLaboratory of Microbiology & Infectious Diseases, The Rockefeller University, New York, New York; Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB-NOVA), Oeiras, Portugal.
Alexander TomaszLaboratory of Microbiology & Infectious Diseases, The Rockefeller University, New York, New York.
Chad W EulerDepartment of Medical Laboratory Sciences, Hunter College, CUNY, New York, New York; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York; Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York.
Rockefeller University · USCornell University · USHospital for Special Surgery · USUniversidade Nova de Lisboa · PT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Lytic enzymes are novel antimicrobial agents that degrade bacterial cell walls, resulting in cell rupture and death. We tested one enzyme, the bacteriocin lysostaphin, for treatment of nonhuman primates (

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsLysostaphinMacaca mulattaMultilocus Sequence TypingPilot ProjectsAnti-Bacterial AgentsLysostaphin

Identifiers

PMID32792040
PMCPMC7574217
OpenAlexW3049004534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.