ArticleBMC musculoskeletal disorders2020
Transient osteoporosis of the hip and subclinical hypothyroidism: an unusual dangerous duet? Case report and pathogenetic hypothesis.
Article in BMC musculoskeletal disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Management of transient bone osteoporosis: a systematic review.British medical bulletin · 2023Pooled it
- Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review.BMC musculoskeletal disorders · 2021Pooled it
- Optimizing diagnosis and management of ONFH, FNSF, and SIF.EFORT open reviews · 2026Review
- Bilateral Transient Osteoporosis of the Hip in Pregnancy: Diagnostic Challenges, MRI-Based Approach, and Multidisciplinary Management.Diseases (Basel, Switzerland) · 2026Article
- Stress fracture of the neck of talus in an adolescent female with hypothyroidism: a case report of an unusual cause of ankle pain.International journal of surgery case reports · 2026Article
- Bilateral subcapital femoral fractures associated with transient osteoporosis of the hip in pregnancy: a case report.Trauma case reports · 2026Article
- Presence of subchondral fracture in cases diagnosed as transient osteoporosis of the hip: a retrospective independent reader-based study.Skeletal radiology · 2024Article
- Article
- Transient Osteoporosis of Hip Causing Fracture Neck of Femur in Pregnancy.Journal of obstetrics and gynaecology of India · 2022Article
- Challenges and Solutions for Musculoskeletal Disorders in Athletes.Medicina (Kaunas, Lithuania) · 2022Article
- Avascular necrosis of the first metatarsal head in a young female adult: A case report and review of literature.World journal of clinical cases · 2021Article
- The Rationale for the Intra-Articular Administration of Clodronate in Osteoarthritis.International journal of molecular sciences · 2021Review
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient osteoporosis of the hip (TOH) is a rare and temporary clinical condition characterised by bone marrow edema (BME), severe pain, and functional limitation. It commonly occurs in middle-aged men or in women in the last trimester of pregnancy. TOH usually resolves with conservative therapy but may predispose to hip fracture or progression to avascular necrosis (AVN). Etiology is still unclear, although several pathophysiological mechanisms underpinning this condition has been proposed. We describe the management of an unusual case of TOH occurred in a patient with subclinical hypothyroidism. CASE PRESENTATION: A clinical case of a 46-year-old man with severe pain in the left anterior thigh is presented. After a comprehensive clinical and radiological approach, a TOH was diagnosed. Moreover, biochemical assessment suggested the presence of subclinical hypothyroidism. After 3 months of treatment with clodronate, physical therapy and hormone replacement therapy (HRT) a significant improvement of clinical and radiological outcomes was observed.
conclusionSeveral pathological conditions have been related to development of TOH. In our case, we suggested for the first time a role of subclinical hypothyroidism as novel contributory factor for the onset of this condition, providing pathophysiological mechanisms and a scientific rationale for pharmacological treatment.
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