Evidence map›Paper›PMID 32791950›Full record

Trial reportCirculation. Cardiovascular interventions2020

Plaque Regression and Endothelial Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER).

Subhash Banerjee, Ping Luo, Domenic J Reda, Faisal Latif, Jeffrey L Hastings, Ehrin J Armstrong, Jayant Bagai, Mazen Abu-Fadel, Amutharani Baskar, Preeti Kamath and 5 more

Erratum issued 2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Circulation. Cardiovascular interventions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It reports registered trial NCT01004406. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01004406 phase3completed

Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER)

Ran2011Enrolled59Registered outcomes4Posted comparisons0ConditionsAcute Coronary SyndromeArmsintensive LDL-lowering therapy, standard statin monotherapy
Open the trial in the graph
NCT02347098 phase3completed

Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase II

Ran2015Enrolled270Registered outcomes4Posted comparisons4ConditionsAcute Coronary Artery SyndromeArmsintensive LDL-lowering therapy, standard statin monotherapy
Open the trial in the graph
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Teaching Old Treatments New Tricks.Circulation. Cardiovascular interventions · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Subhash BanerjeeVeterans Affairs North Texas Health Care System, Dallas (S.B., J.L.H.).
Ping LuoCooperative Studies Program Coordinating Center, Edward Hines, Jr Veterans Affairs Hospital, Hines, IL (P.L., D.J.R., D.L., Y.W.).
Domenic J RedaCooperative Studies Program Coordinating Center, Edward Hines, Jr Veterans Affairs Hospital, Hines, IL (P.L., D.J.R., D.L., Y.W.).
Faisal LatifOklahoma City Veterans Affairs Medical Center (F.L.).
Jeffrey L HastingsVeterans Affairs North Texas Health Care System, Dallas (S.B., J.L.H.).
Ehrin J ArmstrongRocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO (E.J.A.).
Jayant BagaiVeterans Affairs Tennessee Valley Health Care System, Nashville (J.B.).
Mazen Abu-FadelUniversity of Oklahoma Health Sciences Center (F.L., M.A.-F.).
Amutharani BaskarUniversity of Texas Southwestern Medical Center, Dallas (S.B., J.L.H., A.B., P.K.).
Preeti KamathUniversity of Texas Southwestern Medical Center, Dallas (S.B., J.L.H., A.B., P.K.).
Daniel LippeCooperative Studies Program Coordinating Center, Edward Hines, Jr Veterans Affairs Hospital, Hines, IL (P.L., D.J.R., D.L., Y.W.).
Yongliang WeiCooperative Studies Program Coordinating Center, Edward Hines, Jr Veterans Affairs Hospital, Hines, IL (P.L., D.J.R., D.L., Y.W.).
Alexandra ScrymgeourCooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (A.S.).
Theresa C GleasonDepartment of Veterans Affairs, Office of Research and Development, Washington, DC (T.C.G.).
Emmanouil S BrilakisMinneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, MN (E.S.B.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow-density lipoproteins (LDLs) are removed by extracorporeal filtration during LDL apheresis. It is mainly used in familial hyperlipidemia. The PREMIER trial (Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen) evaluated LDL apheresis in nonfamilial hyperlipidemia acute coronary syndrome patients treated with percutaneous coronary intervention.

methodsWe randomized 160 acute coronary syndrome patients at 4 Veterans Affairs centers within 72 hours of percutaneous coronary intervention to intensive lipid-lowering therapy (ILLT) comprising single LDL apheresis and statins versus standard medical therapy (SMT) with no LDL apheresis and statin therapy alone. Trial objectives constituted primary safety and primary efficacy end points and endothelial progenitor cell colony-forming unit mobilization in peripheral blood.

resultsMean LDL reduction at discharge was 53% in ILLT and 17% in SMT groups (

conclusionsPREMIER is the first randomized clinical trial to demonstrate safety and a trend for early coronary plaque regression with LDL apheresis in nonfamilial hyperlipidemia acute coronary syndrome patients treated with percutaneous coronary intervention. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01004406 and NCT02347098.

Indexed as

Blood Component RemovalPercutaneous Coronary InterventionPlaque, AtheroscleroticAcute Coronary SyndromeAgedBiomarkersCombined Modality TherapyCoronary Artery DiseaseEndothelial Progenitor CellsFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasLipoproteins, LDLMaleMiddle AgedBiomarkersHydroxymethylglutaryl-CoA Reductase InhibitorsLipoproteins, LDLacute coronary syndromecoronary artery diseasediabetes mellitushumansincidence

Identifiers

PMID32791950

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.