ArticleCephalalgia : an international journal of headache2020
Migraine and aura triggered by normobaric hypoxia.
Article in Cephalalgia : an international journal of headache, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Single-cell RNA-sequencing reveals cellular heterogeneity and identifies biomarkers for obstructive sleep apnea and migraine.Human genomics · 2026Article
- Erythrocytes as Active Regulators of Blood Flow: A Brief Overview.Advances in experimental medicine and biology · 2026Review
- Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research.British journal of clinical pharmacology · 2026Review
- The mysterious link between migraine aura and migraine headache.PLoS biology · 2025Article
- Mechanisms and clinical applications of the valsalva maneuver in migraine relief: A mini-review.Current journal of neurology · 2025Article
- Migraine and stroke: correlation, coexistence, dependence - a modern perspective.The journal of headache and pain · 2025Review
- Effects of patent foramen ovale in migraine: a metabolomics-based study.The Journal of physiology · 2025Article
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- Short-term efficacy of right-to-left shunt closure in patients with vestibular migraine.Frontiers in neurology · 2024Article
- Article
- Normobaric oxygen may attenuate the headache in patients with patent foramen povale and migraine.BMC neurology · 2023Article
- Selected Factors of Vascular Changes: The Potential Pathological Processes Underlying Primary Headaches in Children.Children (Basel, Switzerland) · 2022Article
- The putative role of trigemino-vascular system in brain perfusion homeostasis and the significance of the migraine attack.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Is Neuronal Fatigue the Cause of Migraine?Brain sciences · 2022Article
- Case report: Monoclonal CGRP-antibody treatment in a migraine patient with a mutation in the mitochondrial single-strand binding protein (SSBP1).Frontiers in neurology · 2022Article
- Hypoxia-related mechanisms inducing acute mountain sickness and migraine.Frontiers in physiology · 2022Review
- Short Report of Longitudinal CGRP-Measurements in Migraineurs During a Hypoxic Challenge.Frontiers in neurology · 2022Article
- Transient and Recurrent Vision Loss in a High-Altitude Porter from Pakistan on a Polish Winter Karakoram Expedition.International journal of environmental research and public health · 2021Article
- Cortical spreading depression and meningeal nociception.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor future experimental studies or the development of targeted pharmaceutical agents, a deeper insight into the pathophysiology of migraine is of utmost interest. Reliable methods to trigger migraine attacks including aura are desirable to study this complex disease
methodsTo investigate hypoxia as a trigger for migraine and aura, we exposed volunteers diagnosed with migraine, with (n = 16) and without aura (n = 14), to hypoxia utilizing a hypoxic chamber adjusted to a FiO
findingsOf 30 participants, 24 (80.0%) developed headaches and 19 (63.3%) migraine, five (16.7%) reported aura. Two patients that developed aura never experienced aura symptoms before in their life. The increase of mean heart frequency was higher in patients developing headaches or migraine. Mean SpO
conclusionHypoxia was able to trigger migraine attacks and aura independently of any pharmacological agent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.