Evidence map›Paper›PMID 32791112›Full record

ReviewCell host & microbe2020

The Skin Microbiota: Balancing Risk and Reward.

Laurice Flowers, Elizabeth A Grice

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell host & microbe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 264 citations in OpenAlex.

  1. Review
  2. Article
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  4. Strain-level genomic analysis ofMicrobiology spectrum · 2026
    Article
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  7. Article
  8. Pharmaceutics · 2026
    Article
  9. Review
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  11. Article
  12. Microbiology and molecular biology reviews : MMBR · 2026
    Review
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  17. Review
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laurice FlowersDepartment of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Elizabeth A GriceDepartment of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: egrice@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0M
Skin microbiome contributions to the pathogenesis of cutaneous leishmaniasisR01AI143790 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, PHILLIP SCOTT · 2019 to 2026
$6.0M
Decoding the microbial burden in diabetic foot ulcersR01NR015639 · NINR · UNIVERSITY OF PENNSYLVANIA · PI GRICE, ELIZABETH ANNE · 2015 to 2023
$4.1M
Skin microbiome interactions with complementR01AR066663 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI GRICE, ELIZABETH ANNE · 2015 to 2019
$1.8M
NIAID NIH HHS R01 AI143790NIAMS NIH HHS R01 AR066663NIAMS NIH HHS T32 AR007465NINR NIH HHS R01 NR015639
6 · The paper itself

Abstract

The skin microbiome is an ecosystem comprised of a multitude of microbial species interacting with their surroundings, including other microbes and host epithelial and immune cells. These interactions are the basis of important roles within the skin microbiome that provide benefit to the host, boosting multiple aspects of barrier function, a critical function of this essential organ. However, with reward always comes risk; resident skin microbes function in a context-dependent manner, set on the backdrop of a dynamic host and microbial milieu. Here, we discuss the reward of hosting a microbial ecosystem on the skin, including protection from pathogens and tuning of the skin microenvironment. We also give consideration to how these skin residents, often termed "commensals" can cause disorder, damage, and promote skin disease.

Indexed as

BacteriaEcosystemFungiHost Microbial InteractionsHumansMicrobiotaSkinSkin DiseasesSymbiosisVirusescommensal microbescutaneous diseasedermatologymicrobiomeskin

Identifiers

PMID32791112
PMCPMC7444652
OpenAlexW3048395252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.