ArticleBipolar disorders2021
A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder.
Article in Bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Frustrative non-reward: A cross-species probe to study brain mechanisms of irritability.Translational psychiatry · 2026Review
- Reward processing disruption in anxiety: fMRI evidence of vulnerability to frustration non-reward.Psychological medicine · 2025Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024Review
- A network approach to the investigation of childhood irritability: probing frustration using social stimuli.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- The association of genetic variation in CACNA1C with resting-state functional connectivity in youth bipolar disorder.International journal of bipolar disorders · 2023Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- Altered spatiotemporal consistency in pediatric bipolar disorder patients with and without psychotic symptoms.BMC psychiatry · 2021Article
- Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.Neuroscience and biobehavioral reviews · 2021Review
- Reduced thalamic resting-state functional connectivity and impaired cognition in acute abstinent heroin users.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesFrustration is associated with impaired attention, heightened arousal, and greater unhappiness in youths with bipolar disorder (BD) vs healthy volunteers (HV). Little is known about functional activation and connectivity in the brain of BD youths in response to frustration. This exploratory study compared BD youths and HV on attentional abilities, self-reported affect, and functional activation and connectivity during a frustrating attention task.
methodsTwenty BD (M
resultsBipolar disorder youths, relative to HV, exhibited positive IFG-ventromedial prefrontal cortex (vmPFC) connectivity yet failed to show negative striatum-insula connectivity during feedback processing. Irritability symptoms were positively associated with striatum-insula connectivity during feedback processing. Moreover, BD vs HV youths showed positive IFG-parahippocampal gyrus (PHG)/periaqueductal gray (PAG) connectivity and negative amygdala-cerebellum connectivity during attention orienting following frustration. BD was not associated with atypical activation patterns.
conclusionsPositive IFG-vmPFC connectivity and striatum-insula decoupling in BD during feedback processing may mediate heightened sensitivity to reward-relevant stimuli. Elevated IFG-PAG/PHG connectivity in BD following frustration may suggest greater recruitment of attention network to regulate arousal and maintain goal-directed behavior.
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