Evidence map›Paper›PMID 32790708›Full record

ArticlePloS one2020

Clinical academic research in the time of Corona: A simulation study in England and a call for action.

Amitava Banerjee, Michail Katsoulis, Alvina G Lai, Laura Pasea, Thomas A Treibel, Charlotte Manisty, Spiros Denaxas, Giovanni Quarta, Harry Hemingway, João L Cavalcante and 2 more

Abstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amitava BanerjeeBarts NHS Trust, London, United Kingdom.ORCID 0000-0001-8741-3411
Michail KatsoulisHealth Data Research UK, University College London, London, United Kingdom.
Alvina G LaiHealth Data Research UK, University College London, London, United Kingdom.
Laura PaseaHealth Data Research UK, University College London, London, United Kingdom.
Thomas A TreibelInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Charlotte ManistyInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Spiros DenaxasHealth Data Research UK, University College London, London, United Kingdom.
Giovanni QuartaDepartment of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Harry HemingwayHealth Data Research UK, University College London, London, United Kingdom.
João L CavalcanteMinneapolis Heart Institute, Minneapolis, Minnesota, United States America.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, United Kingdom.
James C MoonBarts NHS Trust, London, United Kingdom.

Funding

British Heart Foundation FS/18/5/33319British Heart Foundation FS/19/35/34374Medical Research Council MC_PC_13041Medical Research Council MR/K006584/1Wellcome Trust
6 · The paper itself

Abstract

objectivesWe aimed to model the impact of coronavirus (COVID-19) on the clinical academic response in England, and to provide recommendations for COVID-related research.

designA stochastic model to determine clinical academic capacity in England, incorporating the following key factors which affect the ability to conduct research in the COVID-19 climate: (i) infection growth rate and population infection rate (from UK COVID-19 statistics and WHO); (ii) strain on the healthcare system (from published model); and (iii) availability of clinical academic staff with appropriate skillsets affected by frontline clinical activity and sickness (from UK statistics).

settingClinical academics in primary and secondary care in England.

participantsEquivalent of 3200 full-time clinical academics in England.

interventionsFour policy approaches to COVID-19 with differing population infection rates: "Italy model" (6%), "mitigation" (10%), "relaxed mitigation" (40%) and "do-nothing" (80%) scenarios. Low and high strain on the health system (no clinical academics able to do research at 10% and 5% infection rate, respectively.

main outcome measuresNumber of full-time clinical academics available to conduct clinical research during the pandemic in England.

resultsIn the "Italy model", "mitigation", "relaxed mitigation" and "do-nothing" scenarios, from 5 March 2020 the duration (days) and peak infection rates (%) are 95(2.4%), 115(2.5%), 240(5.3%) and 240(16.7%) respectively. Near complete attrition of academia (87% reduction, <400 clinical academics) occurs 35 days after pandemic start for 11, 34, 62, 76 days respectively-with no clinical academics at all for 37 days in the "do-nothing" scenario. Restoration of normal academic workforce (80% of normal capacity) takes 11, 12, 30 and 26 weeks respectively.

conclusionsPandemic COVID-19 crushes the science needed at system level. National policies mitigate, but the academic community needs to adapt. We highlight six key strategies: radical prioritisation (eg 3-4 research ideas per institution), deep resourcing, non-standard leadership (repurposing of key non-frontline teams), rationalisation (profoundly simple approaches), careful site selection (eg protected sites with large academic backup) and complete suspension of academic competition with collaborative approaches.

Indexed as

BetacoronavirusBiomedical ResearchCoronavirus InfectionsCOVID-19Delivery of Health CareEnglandFollow-Up StudiesHealth PersonnelHealth WorkforceHumansModels, StatisticalPandemicsPneumonia, ViralProspective StudiesPublic HealthSARS-CoV-2

Identifiers

PMID32790708
PMCPMC7425844

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.