Evidence map›Paper›PMID 32790682›Full record

ArticlePloS one2020

Selective enhancement of cardiomyocyte efficiency results in a pernicious heart condition.

Jody Groenendyk, Qian Wang, Cory Wagg, Dukgyu Lee, Alison Robinson, Amy Barr, Peter E Light, Gary D Lopaschuk, Luis B Agellon, Marek Michalak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jody GroenendykDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Qian WangDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Cory WaggDepartment of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Dukgyu LeeSchool of Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, Canada.
Alison RobinsonDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Amy BarrDepartment of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Peter E LightDepartment of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Gary D LopaschukDepartment of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Luis B AgellonSchool of Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, Canada.
Marek MichalakDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-9343-9084
University of Alberta · CAMcGill University · CA

Funding

CIHR MOP-15291CIHR PS-153325CIHR PS-168843
6 · The paper itself

Abstract

Transgenic mice with selective induction of calreticulin transgene expression in cardiomyocytes (CardiacCRT+) were analyzed. CardiacCRT+ cardiomyocytes showed increased contractility and Ca2+ transients. Yet, in vivo assessment of cardiac performance, and ischemic tolerance of CardiacCRT+ mice demonstrated right ventricle dilation and reduced cardiac output, increased QT interval and decreased P amplitude. Paradoxically, ex vivo working hearts from CardiacCRT+ mice showed enhanced ischemic cardio-protection and cardiac efficiency. Under aerobic conditions, CardiacCRT+ hearts showed less efficient cardiac function than sham control hearts due to an increased ATP production from glycolysis relative to glucose oxidation. During reperfusion, this inefficiency was reversed, with CardiacCRT+ hearts exhibiting better functional recovery and increased cardiac efficiency compared to sham control hearts. On the other hand, mechanical stretching of isolated cardiac fibroblasts activated the IRE1α branch of the unfolded protein response pathway as well as induction of Col1A2 and TGFβ gene expression ex vivo, which were all suppressed by tauroursodeoxycholic acid.

Indexed as

Myocardial ContractionAnimalsCalreticulinCells, CulturedEnergy MetabolismHeart RateMiceMice, Inbred C57BLMice, TransgenicMyocardial IschemiaMyocytes, CardiacUp-RegulationCalreticulin

Identifiers

PMID32790682
PMCPMC7425937
OpenAlexW3049242176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.