ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020
Variations in loop gain and arousal threshold during NREM sleep are affected by time of day over a 24-hour period in participants with obstructive sleep apnea.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Review
- The upper airway in obstructive sleep apnoea: state of the art.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Review
- Mechanisms and Management of Obstructive Sleep Apnea: A Translational Overview.Clinical and experimental otorhinolaryngology · 2025Review
- Neuro-Ophthalmological Disorders Associated with Obstructive Sleep Apnoea.International journal of molecular sciences · 2025Review
- Article
- Reply to ChenAmerican journal of respiratory and critical care medicine · 2022Article
- Pathophysiology of Obstructive Sleep Apnea in Aging Women.Current sleep medicine reports · 2021Article
- A comprehensive review of respiratory, autonomic and cardiovascular responses to intermittent hypoxia in humans.Experimental neurology · 2021Review
- New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences.Frontiers in neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated whether time of day affects loop gain (LG) and the arousal threshold (AT) during non-rapid eye movement (NREM) sleep. Eleven men with obstructive sleep apnea (apnea-hypopnea index > 5 events/h) completed a constant-routine protocol that comprised 3-h sleep sessions in the evening [10 PM (1) to 1 AM], morning (6 AM to 9 AM), afternoon (2 PM to 5 PM), and subsequent evening [10 PM (2) to 1 AM]. During each sleep session LG and the AT were measured during NREM sleep with a model-based approach. Our results showed the presence of a rhythmicity in both LG (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.