Evidence map›Paper›PMID 32790508›Full record

ArticleThe Journal of international medical research2020

Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population.

Jia Fan, Yaoliang Shen, Bo Chen, Chunyang Xu, Hongwei Ye, Jian Wang, Wenjun Zhou, Yuefeng Sheng, Feng Xu, Peng Yang

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Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jia FanChangshu First People's Hospital Affiliated to Soochow University, Changshu, Jiangsu, China.ORCID https://orcid.org/0000-0002-2924-2156
Yaoliang ShenChangshu First People's Hospital Affiliated to Soochow University, Changshu, Jiangsu, China.
Bo ChenChangshu First People's Hospital Affiliated to Soochow University, Changshu, Jiangsu, China.
Chunyang XuChangshu First People's Hospital Affiliated to Soochow University, Changshu, Jiangsu, China.
Hongwei YeChangshu First People's Hospital Affiliated to Soochow University, Changshu, Jiangsu, China.ORCID https://orcid.org/0000-0003-0374-5406
Jian WangThe Fifth People's Hospital of Changshu, Changshu, Jiangsu, China.
Wenjun ZhouThe Fifth People's Hospital of Changshu, Changshu, Jiangsu, China.ORCID https://orcid.org/0000-0003-3312-9321
Yuefeng ShengChangshu Medical Emergency Center, Changshu, Jiangsu, China.
Feng XuEmergency Department, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Peng YangEmergency Department, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID https://orcid.org/0000-0003-2967-4108

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated whether the CYP11B2 -344T/C polymorphism is correlated with transient ischemic attack (TIA) susceptibility.

methodsWe recruited 100 TIA patients and 100 control subjects and analyzed the CYP11B2 -344T/C polymorphism using restriction fragment length polymorphism (PCR-RFLP).

resultsThe frequency in TIA patients and controls was 42% compared with 48% for TT genotypes, 51% compared with 45% for TC genotypes, and 7% compared with 7% for CC genotype, respectively. Allele frequencies in TIA patients and controls were 67.5% compared with 70.5% for T-allele and 32.5% compared with 29.5% for C-allele, respectively. No association between the CYP11B2 -344T/C polymorphism and TIA was observed in all comparisons.

conclusionOur data suggest that there was no association between the CYP11B2 -344T/C polymorphism and TIA in a Chinese population.

Indexed as

HypertensionIschemic Attack, TransientChinaCytochrome P-450 CYP11B2Gene FrequencyGenotypeHumansPolymorphism, GeneticCytochrome P-450 CYP11B2alleleAngiotensin-converting enzyme geneCYP11B2polymorphismrestriction fragment length polymorphismtransient ischemic attack

Identifiers

PMID32790508
PMCPMC7427132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.