ArticleDevelopmental science2021
The role of the corpus callosum in language network connectivity in children.
Article in Developmental science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07136636 (Investigating the Prognostic Accuracy of Different Biomarkers for Detection of Developmental Language Disorder in Children With Neonatal Encephalopathy), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Prognostic Accuracy of Different Biomarkers for Detection of Developmental Language Disorder in Children With Neonatal Encephalopathy
Who cites it
21 citing papers in PubMed.
- Spatiotemporal white-matter development across early childhood.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Language laterality and cognitive skills: does anatomy matter?Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Tractography-based correlation of diffusion anisotropy metrics in chronic post-stroke aphasia.BMC medical imaging · 2026Article
- Alterations in Corpus Callosum Subregion Microstructure Associated With Visual Dysfunction in Individuals With Cerebral Visual Impairment.Behavioural neurology · 2026Observational
- Article
- Intrahemispheric White Matter Asymmetries and Interhemispheric Connections Underlying the Lateralization of Language Production and Spatial Attention in Left-Handers.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Article
- Corpus Callosum Abnormalities at Term-Equivalent Age Are Associated with Language Development at 2 Years' Corrected Age in Infants Born Very Preterm.Journal of pediatrics. Clinical practice · 2024Article
- Weighting the structural connectome: Exploring its impact on network properties and predicting cognitive performance in the human brain.Network neuroscience (Cambridge, Mass.) · 2024Article
- Volumetric and diffusion MRI abnormalities associated with dysarthria in multiple sclerosis.Brain communications · 2024Article
- Corpus callosum abnormalities at term-equivalent age are associated with language development at two years corrected age in infants born very preterm.medRxiv : the preprint server for health sciences · 2023Article
- Larger corpus callosum volume is favorable for theory of mind development in healthy children.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Assessment of the corpus callosum size in male individuals with high intelligence quotient (members of Mensa International).Radiologie (Heidelberg, Germany) · 2023Article
- White matter microstructure and receptive vocabulary in children with cerebral palsy: The role of interhemispheric connectivity.PloS one · 2023Article
- Neural network bases of thematic semantic processing in language production.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- The importance of deep speech phenotyping for neurodevelopmental and genetic disorders: a conceptual review.Journal of neurodevelopmental disorders · 2022Review
- Article
- Effect of corpus callosum agenesis on the language network in children and adolescents.Brain structure & function · 2021Article
- The role of the corpus callosum in language network connectivity in children.Developmental science · 2021Article
- Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma.BioMed research international · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
The specific role of the corpus callosum (CC) in language network organization remains unclear, two contrasting models have been proposed: inhibition of homotopic areas allowing for independent functioning of the hemispheres versus integration of information from both hemispheres. This study aimed to add to this discussion with the first investigation of language network connectivity in combination with CC volume measures. In 38 healthy children aged 6-12, we performed task-based functional magnetic resonance imaging to measure language network connectivity, used structural magnetic resonance imaging to quantify CC subsection volumes, and administered various language tests to examine language abilities. We found an increase in left intrahemispheric and bilateral language network connectivity and a decrease in right intrahemispheric connectivity associated with larger volumes of the posterior, mid-posterior, and central subsections of the CC. Consistent with that, larger volumes of the posterior parts of the CC were significantly associated with better verbal fluency and vocabulary, the anterior CC volume was positively correlated with verbal span. Thus, children with larger volumes of CC subsections showed increased interhemispheric language network connectivity and were better in different language domains. This study presents the first evidence that the CC is directly linked to language network connectivity and underlines the excitatory role of the CC in the integration of information from both hemispheres.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.