ArticleAging cell2020
Body weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family.
Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Loss of epigenetic adaptation to a high-fat diet in alpha-synuclein transgenic mice.Frontiers in cellular neuroscience · 2026Article
- Construction and validation of a novel nutrient-based index for risk of aging using an interpretable machine learning framework: results from two population-based studies.Nutrition journal · 2025Article
- Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Epigenetic study of the long-term effects of gulf War illness.Frontiers in genetics · 2025Article
- Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model.GeroScience · 2024Article
- Epigenetic regulation of drug metabolism in aging: utilizing epigenetics to optimize geriatric pharmacotherapy.Pharmacogenomics · 2024Review
- Article
- Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process.The journal of nutrition, health & aging · 2023Article
- Insulin and aging - a disappointing relationship.Frontiers in endocrinology · 2023Review
- Epigenetic analysis in a murine genetic model of Gulf War illness.Frontiers in toxicology · 2023Article
- Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.Nutrients · 2022Review
- Article
- Article
- New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork.Genes · 2022Article
- Review
- Somatotropic Axis, Pace of Life and Aging.Frontiers in endocrinology · 2022Review
- Epigenetic Clocks for Mice Based on Age-Associated Regions That are Conserved Between Mouse Strains and Human.Frontiers in cell and developmental biology · 2022Article
- Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.Nature metabolism · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
DNA methylation (DNAm) is shaped by genetic and environmental factors and modulated by aging. Here, we examine interrelations between epigenetic aging, body weight (BW), and life span in 12 isogenic strains from the BXD family of mice that exhibit over twofold variation in longevity. Genome-wide DNAm was assayed in 70 liver specimens from predominantly female cases, 6-25 months old, that were maintained on normal chow or high-fat diet (HFD). We defined subsets of CpG regions associated with age, BW at young adulthood, and strain-by-diet-dependent life span. These age-associated differentially methylated CpG regions (age-DMRs) featured distinct genomic characteristics, with DNAm gains over time occurring in sites such as promoters and exons that have high CpG density and low average methylation. CpG regions associated with BW were enriched in introns, tended to have lower methylation in mice with higher BW, and were inversely correlated with gene expression (i.e., higher mRNA levels in mice with higher BW). CpG regions associated with life span were linked to genes involved in life span modulation, including the telomerase reverse transcriptase gene, Tert, which had both lower methylation and higher expression in long-lived strains. An epigenetic clock defined from age-DMRs revealed accelerated aging in mice belonging to strains with shorter life spans. Both higher BW and the HFD were associated with accelerated epigenetic aging. Our results highlight the age-accelerating effect of heavier BW. Furthermore, we demonstrate that the measure of epigenetic aging derived from age-DMRs can predict genotype and diet-induced differences in life span among female BXD members.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.