Evidence map›Paper›PMID 32789803›Full record

ArticleStem cell reviews and reports2020

Nicotinamide Inhibits Self-renewal and Induces Granulocyte Differentiation of Multipotent Progenitor Cells.

Waseem Nasr, Claire Fabian, Katrin Arnold, Ulrike Köhl, Ulrich Sack, Ronald Weiss, Michael Cross, Sunna Hauschildt

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Article in Stem cell reviews and reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Waseem NasrMedical Faculty, Institute of Clinical Immunology, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany.
Claire FabianFraunhofer Institute for Cell Therapy and Immunology, Perlickstraße 1, 04103, Leipzig, Germany.
Katrin ArnoldFraunhofer Institute for Cell Therapy and Immunology, Perlickstraße 1, 04103, Leipzig, Germany.
Ulrike KöhlMedical Faculty, Institute of Clinical Immunology, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany.
Ulrich SackMedical Faculty, Institute of Clinical Immunology, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany.
Ronald WeissMedical Faculty, Institute of Clinical Immunology, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany.
Michael CrossHematology and Cellular Therapy, University Hospital Leipzig, Medical Clinic and Policlinic 1, Johannisallee 32a, 04103, Leipzig, Germany.
Sunna HauschildtMedical Faculty, Institute of Clinical Immunology, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany. shaus@rz.uni-leipzig.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide (NAM) a form of vitamin B3, is an essential precursor of NAD. This dinucleotide (pyridine nucleotide) participates in the regulation of fundamental processes including transcription, cell cycle progression and DNA repair. Here we assessed the effect of NAM on myeloid differentiation of the IL-3 dependent, multipotent hematopoietic progenitor cell line FDCP-Mix. We found that NAM reduces the pSTAT5 signaling response, cell cycling and self-renewal potential. It initiates an atypical program of myeloid differentiation that results in the emergence of granulocytic cells in the absence of added myeloid differentiation factors. NAM did not affect the expression the of cell surface granulocyte marker GR1 but led to a strong downregulation of MHC-II molecules. Taken together our data show that NAM induces a differentiation program in hematopoietic progenitors prompting them to undergo differentiation along the granulocyte path without reaching the status of fully developed granulocytes. Graphical abstract.

Indexed as

BiomarkersCell CycleCell DifferentiationCell LineCell ProliferationCell Self RenewalCell ShapeCell SurvivalColony-Forming Units AssayGranulocytesHumansInterleukin-3Multipotent Stem CellsNiacinamidePhosphorylationSTAT5 Transcription FactorBiomarkersInterleukin-3NiacinamideSTAT5 Transcription FactorGranulocyte differentiationNicotinamideProgenitor cellsSelf-renewal

Identifiers

PMID32789803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.