Evidence map›Paper›PMID 32789793›Full record

ArticleEuropean child & adolescent psychiatry2021

Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior.

Julia E Werhahn, Susanna Mohl, David Willinger, Lukasz Smigielski, Alexander Roth, Christoph Hofstetter, Philipp Stämpfli, Jilly Naaijen, Leandra M Mulder, Jeffrey C Glennon and 25 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European child & adolescent psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 9 institutions in 5 countries.

Julia E WerhahnDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland. julia.werhahn@gmx.ch.ORCID http://orcid.org/0000-0003-2837-1674
Susanna MohlDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
David WillingerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Lukasz SmigielskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Alexander RothDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Christoph HofstetterDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Philipp StämpfliDepartment of Psychiatry, Psychotherapy and Psychosomatics and Department of Child and Adolescent Psychiatry, Psychiatric Hospital, MR-Center, University of Zurich, Zurich, Switzerland.
Jilly NaaijenDonders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Leandra M MulderDonders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Jeffrey C GlennonDonders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Andrea DietrichDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Renee Kleine DetersDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pascal M AggensteinerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/ Heidelberg University, Mannheim, Germany.
Nathalie E HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/ Heidelberg University, Mannheim, Germany.
Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/ Heidelberg University, Mannheim, Germany.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/ Heidelberg University, Mannheim, Germany.
Melanie C SaamDepartment of Child and Adolescent Psychiatry/Psychotherapy, University Hospital, University of Ulm, Ulm, Germany.
Ulrike M E SchulzeDepartment of Child and Adolescent Psychiatry/Psychotherapy, University Hospital, University of Ulm, Ulm, Germany.
David J LythgoeDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Arjun SethiDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Michael C CraigDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Mathilde MastroianniDepartment of Child Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Ilyas Sagar-OuriaghliDepartment of Child Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Paramala J SantoshDepartment of Child Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Mireia RosaChild and Adolescent Psychiatry Department, Hospital Clinic of Barcelona, IDIBAPS, Barcelona, Spain.
Nuria BargalloClinic Image Diagnostic Center (CDIC), Hospital Clinic of Barcelona, Magnetic Resonance Image Core Facility, IDIBAPS, Barcelona, Spain.
Josefina Castro-FornielesChild and Adolescent Psychiatry and Psychology Department, Institute Clinic of Neurosciences, Hospital Clinic of Barcelona, CIBERSAM, IDIBAPS, Department of Medicine, University of Barcelona, Barcelona, Spain.
Celso ArangoChild and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, IiSGM, CIBERSAM, Universidad Complutense, Madrid, Spain.
Maria J PenzolChild and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, IiSGM, CIBERSAM, Universidad Complutense, Madrid, Spain.
Marcel P ZwiersDonders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands.
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Jan K BuitelaarDonders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland. brandeis@kjpd.uzh.ch.
University of Zurich · CHKing's College London · GBRadboud University Nijmegen · NLHeidelberg University · DEUniversity Medical Center Groningen · NLHospital Clínic de Barcelona · ESHospital General Universitario Gregorio Marañón · ESUniversität Ulm · DECentro de Investigación Biomédica en Red de Salud Mental · ES

Funding

Medical Research Council MR/M013588/1Seventh Framework Programme 602805 (Aggressotype)Seventh Framework Programme no 603016 (MATRICS)
6 · The paper itself

Abstract

There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-unemotional traits are important specifiers in subtyping aggressive behavior along the affective dimension. Accordingly, we examined associations between two aggression subtypes along with callous-unemotional traits using a seed-to-voxel approach. Six functionally relevant seeds were selected to probe the salience and the default mode network, based on their presumed role in aggression. The resting state sequence was acquired from 207 children and adolescents of both sexes [mean age (standard deviation) = 13.30 (2.60); range = 8.02-18.35] as part of a Europe-based multi-center study. One hundred eighteen individuals exhibiting disruptive behavior (conduct disorder/oppositional defiant disorder) with varying comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms were studied, together with 89 healthy controls. Proactive aggression was associated with increased left amygdala-precuneus coupling, while reactive aggression related to hyper-connectivities of the posterior cingulate cortex (PCC) to the parahippocampus, the left amygdala to the precuneus and to hypo-connectivity between the right anterior insula and the nucleus caudate. Callous-unemotional traits were linked to distinct hyper-connectivities to frontal, parietal, and cingulate areas. Additionally, compared to controls, cases demonstrated reduced connectivity of the PCC and left anterior insula to left frontal areas, the latter only when controlling for ADHD scores. Taken together, this study revealed aggression-subtype-specific patterns involving areas associated with emotion, empathy, morality, and cognitive control.

Indexed as

Conduct DisorderProblem BehaviorAdolescentAggressionAmygdalaAttention Deficit and Disruptive Behavior DisordersChildFemaleHumansMagnetic Resonance ImagingMaleAmygdalaCallous-unemotional traitsDefault mode networkFunctional connectivityProactive aggressionReactive aggression

Identifiers

PMID32789793
PMCPMC8310860
OpenAlexW3049570194

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