Evidence map›Paper›PMID 32789792›Full record

ArticlePurinergic signalling2020

Limonene-induced activation of A

Mehaben Patel, Deven Narke, Mangesh Kurade, Kathleen M Frey, Sahith Rajalingam, Armaan Siddiquee, S Jamal Mustafa, Catherine Ledent, Dovenia S Ponnoth

Open access · bronzeAbstract read
In one paragraph

Article in Purinergic signalling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Related Mechanism of Limonene Improves LPS-Induced Neuroinflammation.Journal of microbiology and biotechnology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. An Updated Comprehensive Review of Plants and Herbal Compounds with Antiasthmatic Effect.Evidence-based complementary and alternative medicine : eCAM · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Analgesic Potential of Terpenes Derived fromPharmacological reviews · 2021
    Review
  17. Adenosine Signaling in Mast Cells and Allergic Diseases.International journal of molecular sciences · 2021
    Review
  18. Adenosine AFrontiers in aging neuroscience · 2021
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Mehaben PatelDivision of Pharmaceutical Sciences Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY, USA.
Deven NarkeDivision of Pharmaceutical Sciences Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY, USA.
Mangesh KuradeDivision of Pharmaceutical Sciences Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY, USA.
Kathleen M FreyFairleigh Dickinson University School of Pharmacy and Health Sciences, Teaneck, NJ, USA.
Sahith RajalingamDivision of Pharmaceutical Sciences Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY, USA.
Armaan SiddiqueeDivision of Pharmaceutical Sciences Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY, USA.
S Jamal MustafaDepartment of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.
Catherine LedentUniversité Libre de Bruxelles, Brussels, Belgium.
Dovenia S PonnothDivision of Pharmaceutical Sciences Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY, USA. dponnoth@osteo.wvsom.edu.
Long Island University · USFairleigh Dickinson University · USUniversité Libre de Bruxelles · BEWest Virginia School of Osteopathic Medicine · USWest Virginia University · US

Funding

MECHANISMS OF CORONARY FLOW REGULATION BY ADENOSINER01HL027339 · NHLBI · WEST VIRGINIA UNIVERSITY · PI MUSTAFA, S. JAMAL · 1986 to 2015
$5.0M
NHLBI NIH HHS R01 HL027339NIH HHS HL027339
6 · The paper itself

Abstract

Animal models of asthma have shown that limonene, a naturally occurring terpene in citrus fruits, can reduce inflammation and airway reactivity. However, the mechanism of these effects is unknown. We first performed computational and molecular docking analyses that showed limonene could bind to both A

Indexed as

AnimalsAsthmaDisease Models, AnimalInflammationLimoneneLungMiceMice, TransgenicOvalbuminReceptor, Adenosine A2ALimoneneOvalbuminReceptor, Adenosine A2AA2A adenosine receptorsAirway inflammationAirway responsivenessAsthmaLimonene

Identifiers

PMID32789792
PMCPMC7524888
OpenAlexW3049361558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.