Evidence map›Paper›PMID 32789756›Full record

ArticleEuropean radiology2021

Automated quantification of COVID-19 severity and progression using chest CT images.

Jiantao Pu, Joseph K Leader, Andriy Bandos, Shi Ke, Jing Wang, Junli Shi, Pang Du, Youmin Guo, Sally E Wenzel, Carl R Fuhrman and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. CT-Derived Features as Predictors of Clot Burden and Resolution.Bioengineering (Basel, Switzerland) · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Jiantao PuDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA. jip13@pitt.edu.ORCID http://orcid.org/0000-0003-2127-5313
Joseph K LeaderDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Andriy BandosDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Shi KeDepartment of Radiology, Xi'an Jiaotong University The First Affiliated Hospital, Xi'an, Shaanxi, China.
Jing WangDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Junli ShiDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Pang DuDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Youmin GuoDepartment of Radiology, Xi'an Jiaotong University The First Affiliated Hospital, Xi'an, Shaanxi, China.
Sally E WenzelDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Carl R FuhrmanDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
David O WilsonDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Frank C SciurbaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Chenwang JinDepartment of Radiology, Xi'an Jiaotong University The First Affiliated Hospital, Xi'an, Shaanxi, China. jin1115@mail.xjtu.edu.cn.
University of Pittsburgh · USFirst Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

Macro-vasculature: A Novel Image Biomarker of Lung CancerR01CA237277 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PU, JIANTAO · 2020 to 2024
$2.8M
CT Assessment of Lung Fissures: Anatomy and Correlated FunctionR01HL096613 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PU, JIANTAO · 2010 to 2019
$1.9M
Foundation for the National Institutes of Health R01CA237277Foundation for the National Institutes of Health R01HL096613NCI NIH HHS R01 CA237277NHLBI NIH HHS R01 HL096613
6 · The paper itself

Abstract

objectiveTo develop and test computer software to detect, quantify, and monitor progression of pneumonia associated with COVID-19 using chest CT scans.

methodsOne hundred twenty chest CT scans from subjects with lung infiltrates were used for training deep learning algorithms to segment lung regions and vessels. Seventy-two serial scans from 24 COVID-19 subjects were used to develop and test algorithms to detect and quantify the presence and progression of infiltrates associated with COVID-19. The algorithm included (1) automated lung boundary and vessel segmentation, (2) registration of the lung boundary between serial scans, (3) computerized identification of the pneumonitis regions, and (4) assessment of disease progression. Agreement between radiologist manually delineated regions and computer-detected regions was assessed using the Dice coefficient. Serial scans were registered and used to generate a heatmap visualizing the change between scans. Two radiologists, using a five-point Likert scale, subjectively rated heatmap accuracy in representing progression.

resultsThere was strong agreement between computer detection and the manual delineation of pneumonic regions with a Dice coefficient of 81% (CI 76-86%). In detecting large pneumonia regions (> 200 mm

conclusionThe preliminary results suggested the feasibility of using computer software to detect and quantify pneumonic regions associated with COVID-19 and to generate heatmaps that can be used to visualize and assess progression. KEY POINTS: • Both computer vision and deep learning technology were used to develop computer software to quantify the presence and progression of pneumonia associated with COVID-19 depicted on CT images. • The computer software was tested using both quantitative experiments and subjective assessment. • The computer software has the potential to assist in the detection of the pneumonic regions, monitor disease progression, and assess treatment efficacy related to COVID-19.

Indexed as

SoftwareAdultAlgorithmsCOVID-19Deep LearningDisease ProgressionHumansLungMiddle AgedRetrospective StudiesSARS-CoV-2Tomography, X-Ray ComputedBiomarkersCOVID-19Neural networkPneumonia

Identifiers

PMID32789756
PMCPMC7755837
OpenAlexW3048657539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.