ArticleCell and tissue research2020
Structural and functional consequences in the amygdala of leptin-deficient mice.
Article in Cell and tissue research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Perspectives on obesity imaging: [International journal of obesity (2005) · 2025Article
- Leptin receptor reactivation restores brain function in early-life Lepr-deficient mice.Brain : a journal of neurology · 2024Article
- Elucidation of the effects of 2,5-hexandione as a metabolite ofToxicological research · 2024Article
- Influence of leptin and its receptors on individuals under chronic social stress behavior.Frontiers in endocrinology · 2024Article
- Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels.Psychological medicine · 2023Article
- Diabetes and cognitive decline: Challenges and future direction.World journal of diabetes · 2023Review
- Article
- Neurotrophic Factors and Dendritic Spines.Advances in neurobiology · 2023Article
- Alteration in the number of neuronal and non-neuronal cells in mouse models of obesity.Brain communications · 2023Article
- Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice.Nature communications · 2021Article
- Targeting Insulin Resistance to Treat Cognitive Dysfunction.Molecular neurobiology · 2021Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On the one hand, the emotional state can influence food intake and on the other hand, hunger can have an impact on the emotional state. Leptin, which is encoded by the ob gene, is involved in the energy homeostasis and plays a role in development of obesity. Mice deficient for leptin (ob/ob) are obese and display several behavioral alterations. It has been shown that ob/ob mice display striking changes in neuronal plasticity within the limbic system, e.g., hippocampal formation. We focus on alterations in ob/ob mice that can be related to alter processing in another part of the limbic system, the amygdala. ob/ob mice have a higher food consumption than age-matched controls, which might have an impact on the emotional state of these mice. Since the amygdala is involved in emotional processing, we analyze whether ob/ob mice display alterations in plasticity at the electrophysiological and structural level. No changes were seen in dendritic spine densities in the basolateral and lateral (LA) nucleus of the amygdala. Interestingly and in contrast to the hippocampus (Porter et al. 2013), long-term potentiation in the LA was increased in ob/ob mice. Our results indicate that amygdalar and hippocampal synaptic plasticity are regulated in different ways by leptin deficiency in accordance with the different functions of these limbic structures in stress and anxiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.