ArticleJournal of neurology2021
Biological age is a novel biomarker to predict stroke recurrence.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy.GeroScience · 2026Pooled it
- Accelerated biological aging based on DNA methylation clocks is a predictor of stroke occurrence: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Associations between phenotypic age and carotid atherosclerosis among the general population: evidence from a multi-stage study.BMC cardiovascular disorders · 2026Article
- DNA Methylation-Regulated ZDHHC24 Exacerbates the Risk of Intracranial Aneurysms.Brain and behavior · 2026Article
- Association of Endothelial Activation and Stress Index with Prognosis in Posterior Circulation Infarcts Treated with Recanalization Therapy.Diagnostics (Basel, Switzerland) · 2025Article
- Association of biological age acceleration with poor outcome after endovascular thrombectomy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Article
- Association of phenotypic age and accelerated aging with severity and disability in patients with acute ischemic stroke.The journal of nutrition, health & aging · 2024Article
- Ischemic Stroke and the Biological Hallmarks of Aging.Aging and disease · 2024Review
- Early-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants.BMC public health · 2024Article
- The Role of Epigenetics in Brain Aneurysm and Subarachnoid Hemorrhage: A Comprehensive Review.International journal of molecular sciences · 2024Review
- Transcriptome-Wide 5-Methylcytosine Profiling of lncRNAs in the Mouse Cerebral Ischemia Model.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Potential Protein Signatures for Recurrence Prediction of Ischemic Stroke.Journal of the American Heart Association · 2024Article
- Protein Biomarkers in Blood Reflect the Interrelationships Between Stroke Outcome, Inflammation, Coagulation, Adhesion, Senescence and Cancer.Cellular and molecular neurobiology · 2023Review
- Machine Learning Approximations to Predict Epigenetic Age Acceleration in Stroke Patients.International journal of molecular sciences · 2023Article
- Association between kidney function and biological age: a China Health and Retirement Longitudinal Study.Frontiers in public health · 2023Article
- Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age.Biology · 2022Article
- Retinal age gap as a predictive biomarker of stroke risk.BMC medicine · 2022Article
- Epigenetic mechanisms and potential therapeutic targets in stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundStroke recurrence (SR) after an ischemic stroke is an important cause of death and disability. We conducted a hospital-based study to evaluate the role of biological age (b-Age: age-related DNA-methylation changes) as a risk factor for SR.
methodsWe included 587 patients in the acute phase of stroke, assessed at one tertiary stroke center (Hospital del Mar: Barcelona, Spain). B-Age was estimated with 5 different methods based on DNA methylation, and Hannum's method was the one that better performed. We analyzed the relationships between b-Age, chronological age, sex, vascular risk factors, coronary and peripheral arterial disease, atrial fibrillation, initial neurological severity assessed by National Institutes of Health Stroke Scale (NIHSS), transient ischemic attack (TIA) in the 7 days preceding the index stroke, and symptomatic atherosclerosis. Stroke recurrence definition include: new symptoms that suggest a new ischemic event had occurred within 3 months after stroke onset and worsening by four points in the initial neurological severity (measured by National Institutes of Health Stroke Scale (NIHSS) score).
resultsLogistic regression analysis associated b-Age with SR [p = 0.003; OR = 1.06 (95% CI: 1.02-1.09)], independently of chronological age [p = 0.022; OR = 0.96 (95% CI 0.94-1.00)], symptomatic atherosclerosis (stenosis > 50% in the symptomatic territory), transient ischemic attack (TIA) in the 7 days preceding the index stroke, and initial NIHSS. The b-Age of patients with SR was 2.7 years older than patients without SR.
conclusionsPatients with SR were biologically older than those without SR. B-Age was independently associated with high risk of developing SR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.