ArticleNeuro-oncology2021
Functional connectivity within glioblastoma impacts overall survival.
Article in Neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Leveraging neuroscience imaging and electrophysiological assessments to decode neuron-glioma interactions.Neuro-oncology advances · 2026Review
- Anomaly Detection for Structural and Functional Connectivity in Glioma Patients.NMR in biomedicine · 2026Article
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- A non-local diffusion magnetic resonance imaging tract density biomarker to stratify, predict, and interpret survival rates in human glioblastoma.Neuro-oncology · 2026Article
- BOLD complexity characterizes glioblastoma survival via voxel-wise and localized sample entropy.Journal of neuro-oncology · 2026Article
- Beyond synapses non-synaptic neural microenvironment interactions remodel circuits and drive glioma progression.Frontiers in oncology · 2026Review
- Structural-functional fingerprinting for abnormalities investigation in glioma patients.Scientific reports · 2025Article
- Predicting attention deficits and functional recovery after glioma resection through functional executive networks: insights from dynamic properties.Journal of neuro-oncology · 2025Article
- Models of High-Grade Glioma in Rats: Morphology, Size, Thickness of Cerebral Cortex, and Survival.Bulletin of experimental biology and medicine · 2025Article
- Individual-level metabolic connectivity from dynamic [European journal of nuclear medicine and molecular imaging · 2025Article
- Inferring the genetic relationships between unsupervised deep learning-derived imaging phenotypes and glioblastoma through multi-omics approaches.Briefings in bioinformatics · 2024Article
- The promise of precision functional mapping for neuroimaging in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Pseudo-Resting-State Functional MRI Derived from Dynamic Susceptibility Contrast Perfusion MRI Can Predict Cognitive Impairment in Glioma.AJNR. American journal of neuroradiology · 2024Article
- Predicting post-surgical functional status in high-grade glioma with resting state fMRI and machine learning.Journal of neuro-oncology · 2024Article
- Central nervous system regulation of diffuse glioma growth and invasion: from single unit physiology to circuit remodeling.Journal of neuro-oncology · 2024Review
- Structural connectome combining DTI features predicts postoperative language decline and its recovery in glioma patients.European radiology · 2024Article
- Tumour-infiltrated cortex participates in large-scale cognitive circuits.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Systematic Review Between Resting-State fMRI and Task fMRI in Planning for Brain Tumour Surgery.Journal of multidisciplinary healthcare · 2024Review
- ELF4 was a prognostic biomarker and related to immune infiltrates in glioma.Journal of Cancer · 2024Article
- Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients.Brain imaging and behavior · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundGlioblastoma (GBM; World Health Organization grade IV) assumes a variable appearance on MRI owing to heterogeneous proliferation and infiltration of its cells. As a result, the neurovascular units responsible for functional connectivity (FC) may exist within gross tumor boundaries, albeit with altered magnitude. Therefore, we hypothesize that the strength of FC within GBMs is predictive of overall survival.
methodsWe used predefined FC regions of interest (ROIs) in de novo GBM patients to characterize the presence of within-tumor FC observable via resting-state functional MRI and its relationship to survival outcomes.
resultsFifty-seven GBM patients (mean age, 57.8 ± 13.9 y) were analyzed. Functionally connected voxels, not identifiable on conventional structural images, can be routinely found within the tumor mass and was not significantly correlated to tumor size. In patients with known survival times (n = 31), higher intranetwork FC strength within GBM tumors was associated with better overall survival even after accounting for clinical and demographic covariates.
conclusionsThese findings suggest the possibility that functionally intact regions may persist within GBMs and that the extent to which FC is maintained may carry prognostic value and inform treatment planning.
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