ArticleProgress in rehabilitation medicine2018
Systemic Inflammation in the Recovery Stage of Stroke: Its Association with Sarcopenia and Poor Functional Rehabilitation Outcomes.
Article in Progress in rehabilitation medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Prevalence of Stroke-Related Sarcopenia: A Systematic Review and Meta-Analysis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Pooled it
- Prevalence and risk factors of sarcopenia in patients with stroke: a systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Trajectories of the Prevalence of Sarcopenia in the Pre- and Post-Stroke Periods: A Systematic Review.Nutrients · 2022Pooled it
- Admission Systemic Immune-Inflammation Index Is Associated with Cognitive Performance and Handgrip Strength Three Months After First-Ever Acute Ischaemic Stroke: A Prospective Cohort Study.Brain sciences · 2026Article
- Initial Phase Angle Is Independently Associated With Functional Independence at 6 Months After Stroke.Geriatrics & gerontology international · 2026Observational
- A practical estimation equation for appendicular skeletal muscle mass in stroke rehabilitation: validating diagnostic accuracy and predicting functional outcomes.European geriatric medicine · 2026Article
- Observational
- Application of Artificial Intelligence in the Prediction and Management of Stroke Rehabilitation.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Narrative Review on Post-Stroke Outcomes Through Recognition of Frailty, Sarcopenia, and Palliative Care Needs.Healthcare (Basel, Switzerland) · 2025Review
- Optimal Cutoff Values of Site-Specific Phase Angle for Predicting Independence in Activities of Daily Living in Post-stroke Patients.Annals of geriatric medicine and research · 2025Article
- Systemic inflammation is associated with gut microbiota diversity in post-stroke patients.European geriatric medicine · 2025Article
- Stroke-related sarcopenia: a scoping review of influencing factors and clinical outcomes.Frontiers in aging · 2025Review
- Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients.Annals of geriatric medicine and research · 2024Article
- Ischemic stroke and sarcopenia have an asymmetric bidirectional relationship based on a two-sample Mendelian randomization study.Frontiers in neurology · 2024Article
- Concurrent Negative Impact of Undernutrition and Heart Failure on Functional and Cognitive Recovery in Hip Fracture Patients.Nutrients · 2023Article
- Stroke-Related Sarcopenia among Two Different Developing Countries with Diverse Ethnic Backgrounds (Cross-National Study in Egypt and China).Healthcare (Basel, Switzerland) · 2022Article
- Article
- Aging after stroke: how to define post-stroke sarcopenia and what are its risk factors?European journal of physical and rehabilitation medicine · 2022Observational
- Sarcopenia and Chronic Complications of Type 2 Diabetes Mellitus.The review of diabetic studies : RDS · 2022Review
- Polypharmacy and potentially inappropriate medications in stroke rehabilitation: prevalence and association with outcomes.International journal of clinical pharmacy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of our study was to investigate how systemic inflammation relates to sarcopenia and its impact on functional outcomes in the recovery stages of stroke.
methodsA retrospective cohort study was performed in consecutive patients admitted to convalescent rehabilitation wards following stroke. Patients with acute or chronic high-grade inflammatory diseases were excluded. Systemic inflammation was evaluated using the modified Glasgow Prognostic Score (mGPS). Sarcopenia was defined as a loss of skeletal muscle mass and decreased muscle strength, with the cut-off values set by the Asian Working Group for Sarcopenia. The primary outcome was the motor domain of the Functional Independence Measure (FIM-motor). Univariate and multivariate analyses were used to determine whether mGPS was associated with sarcopenia and FIM-motor at discharge.
resultsThe study included 204 patients (mean age 74.1 years, 109 men). mGPS scores of 0, 1, and 2 were assigned to 149 (73.0%), 40 (19.6%), and 13 (6.4%) patients, respectively. Sarcopenia was diagnosed in 81 (39.7%) patients and was independently associated with stroke history (odds ratio [OR] 1.890, P=0.027), premorbid modified Rankin scale (OR 1.520, P=0.040), body mass index (OR 0.858, P=0.022), and mGPS score (OR 1.380, P=0.021). Furthermore, the mGPS score was independently associated with sarcopenia (OR 1.380, P=0.021) and FIM-motor at discharge (β=-0.131, P=0.031).
conclusionSystemic inflammation is closely associated with sarcopenia and poor functional outcomes in the recovery stage of stroke. Early detection of systemic inflammation and sarcopenia can help promote both adequate exercise and nutritional support to restore muscle mass and improve post-stroke functional recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.