ArticleTrauma surgery & acute care open2020
β-adrenergic blockade is associated with a reduced risk of 90-day mortality after surgery for hip fractures.
Article in Trauma surgery & acute care open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Beta-Blocker Use in Patients Undergoing Non-Cardiac Surgery: A Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2024Pooled it
- Morbidity prediction in conservatively managed rib fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Metabolic disorders after traumatic brain injury: a narrative review of systemic consequences.Metabolic brain disease · 2025Review
- A nationwide analysis on the interaction between frailty and beta-blocker therapy in hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- The mortality burden of frailty in hip fracture patients: a nationwide retrospective study of cause-specific mortality.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Dementia is a surrogate for frailty in hip fracture mortality prediction.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- The mortality burden in patients with hip fractures and dementia.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- The interaction between pre-admission β-blocker therapy, the Revised Cardiac Risk Index, and mortality in geriatric hip fracture patients.The journal of trauma and acute care surgery · 2022Article
- Mode of anesthesia is not associated with outcomes following emergency hip fracture surgery: a population-level cohort study.Trauma surgery & acute care open · 2022Article
- Article
- Beta-Blocker Therapy Is Associated With Increased 1-Year Survival After Hip Fracture Surgery: A Retrospective Cohort Study.Anesthesia and analgesia · 2021Observational
- Predicting 1-Year Mortality after Hip Fracture Surgery: An Evaluation of Multiple Machine Learning Approaches.Journal of personalized medicine · 2021Article
- Predictive Values of Preoperative Characteristics for 30-Day Mortality in Traumatic Hip Fracture Patients.Journal of personalized medicine · 2021Article
- Orthogeriatric Management: Improvements in Outcomes during Hospital Admission Due to Hip Fracture.International journal of environmental research and public health · 2021Review
- Postoperative mortality in hip fracture patients stratified by the Revised Cardiac Risk Index: a Swedish nationwide retrospective cohort study.Trauma surgery & acute care open · 2021Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a significant postoperative mortality risk in patients subjected to surgery for hip fractures. Adrenergic hyperactivity induced by trauma and subsequent surgery is thought to be an important contributor. By downregulating the effect of circulating catecholamines the increased risk of postoperative mortality may be reduced. The aim of the current study is to assess the association between regular β-blocker therapy and postoperative mortality.
methodsThis cohort study used the prospectively collected Swedish National Quality Registry for hip fractures to identify all patients over 40 years of age subjected to surgery for hip fractures between 2013 and 2017 in Örebro County, Sweden. Patients with ongoing β-blocker therapy at the time of surgery were allocated to the β-blocker-positive cohort. The primary outcome of interest was 90-day postoperative mortality. Risk factors for 90-day mortality were evaluated using Poisson regression analysis.
resultsA total of 2443 patients were included in this cohort of whom 900 (36.8%) had ongoing β-blocker therapy before surgery. The β-blocker positive group was significantly older, less fit for surgery based on their American Society of Anesthesiologists classification and had a higher prevalence of comorbidities. A significant risk reduction in 90-day mortality was detected in patients receiving β-blockers (adjusted incidence rate ratio=0.82, 95% CI 0.68 to 0.98, p=0.03).
conclusionsβ-blocker therapy is associated with a significant reduction in 90-day postoperative mortality after hip fracture surgery. Further investigation into this finding is warranted. LEVEL OF EVIDENCE: Therapeutic study, level III; prognostic study, level II.
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