ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Diagnosing vascular cognitive impairment: Current challenges and future perspectives.International journal of stroke : official journal of the International Stroke Society · 2023Review
- Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease-related brain injury.Brain structure & function · 2022Article
- Neuropsychiatric symptoms in patients with possible vascular cognitive impairment, does sex matter?Cerebral circulation - cognition and behavior · 2022Article
- Vascular Cognitive Impairment and cognitive decline; a longitudinal study comparing different types of vascular brain injury - The TRACE-VCI study.Cerebral circulation - cognition and behavior · 2022Article
- Prevalence of cognitive impairment in Chinese older inpatients and its relationship with 1-year adverse health outcomes: a multi-center cohort study.BMC geriatrics · 2021Article
- Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
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Authors and funding
15 authors at 8 institutions in 3 countries.
Funding
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Abstract
introductionPrognostication in memory clinic patients with vascular brain injury (eg possible vascular cognitive impairment [VCI]) is often uncertain. We created a risk score to predict poor clinical outcome.
methodsUsing data from two longitudinal cohorts of memory clinic patients with vascular brain injury without advanced dementia, we created (n = 707) and validated (n = 235) the risk score. Poor clinical outcome was defined as substantial cognitive decline (change of Clinical Dementia Rating ≥1 or institutionalization) or major vascular events or death. Twenty-four candidate predictors were evaluated using Cox proportional hazard models.
resultsAge, clinical syndrome diagnosis, Disability Assessment for Dementia, Neuropsychiatric Inventory, and medial temporal lobe atrophy most strongly predicted poor outcome and constituted the risk score (C-statistic 0.71; validation cohort 0.78). Of note, none of the vascular predictors were retained in this model. The 2-year risk of poor outcome was 6.5% for the lowest (0-5) and 55.4% for the highest sum scores (10-13). DISCUSSION: This is the first, validated, prediction score for 2-year clinical outcome of patients with possible VCI.
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