ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Increased variability in reaction time is associated with amyloid beta pathology at age 70.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Associations of cognitive intraindividual variability with Alzheimer's disease risk: A systematic review.The Clinical neuropsychologist · 2026Pooled it
- Plasma biomarkers of neurodegeneration and intraindividual cognitive variability: Comparing variability across test at one time point and using repeated ecological momentary assessment.Neuropsychology · 2026Article
- Autistic Trait Level and Reaction Time in Older Adults: The Influence of Sex and Task upon Study Outcome.Autism in adulthood · 2026Article
- Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults.Brain : a journal of neurology · 2025Article
- Using objective and subjective measures of mind wandering to predict progression to development of cognitive impairment and test associations with Alzheimer disease biomarkers.Journal of clinical and experimental neuropsychology · 2025Article
- Health literacy in relation to web-based measurement of cognitive function in the home: UK Women's Cohort Study.BMJ open · 2025Article
- Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's disease.Journal of the International Neuropsychological Society : JINS · 2024Article
- Increased intraindividual variability in reaction time performance is associated with emerging cognitive decline in cognitively unimpaired adults.Neuropsychology · 2024Article
- Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3.BMC neurology · 2024Article
- Resting-state functional connectivity changes in older adults with sleep disturbance and the role of amyloid burden.Molecular psychiatry · 2023Article
- Resting-State Functional Connectivity Changes in Older Adults with Sleep Disturbance and the Role of Amyloid Burden.Research square · 2023Article
- Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort.Neurobiology of aging · 2023Article
- Intraindividual Cognitive Variability and Magnetic Resonance Imaging in Aging American Indians: Data from the Strong Heart Study.Journal of Alzheimer's disease : JAD · 2023Article
- Synergistic effects of high early-life stress exposure and HIV infection on reaction time variability.Frontiers in psychology · 2023Article
- Quality of Survey Responses at Older Ages Predicts Cognitive Decline and Mortality Risk.Innovation in aging · 2022Article
- Dissociable effects ofNature aging · 2021Article
- A deep learning approach for monitoring parietal-dominant Alzheimer's disease in World Trade Center responders at midlife.Brain communications · 2021Article
- Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer's disease.Brain communications · 2021Article
- Increased variability in reaction time is associated with amyloid beta pathology at age 70.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Performance change while learning novel cognitive tasks as a potential identifier of preclinical Alzheimer's disease.Journal of Alzheimer's disease reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 1 country.
Funding
Abstract
introductionWe investigated whether life-course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults.
methodsInsight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2-choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra-individual variability in RT) and life-course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ-positivity.
resultsCognitively normal Aβ-positive participants had 10% more variable RTs than Aβ-negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance. DISCUSSION: This study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.