Evidence map›Paper›PMID 32789004›Full record

ReviewF1000Research2020

Recent advances in mechanisms of food allergy and anaphylaxis.

Sunil Tomar, Simon P Hogan

Open access · goldAbstract readReview
In one paragraph

Review in F1000Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Context-dependent regulation of mast cell-mediated food allergy in C57BL/6J mice.The Journal of allergy and clinical immunology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A comprehensive summary of disease variants implicated in metal allergy.Journal of toxicology and environmental health. Part B, Critical reviews · 2022
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sunil Tomar1. Mary H. Weiser Food Allergy Center, Department of Pathology, University of Michigan 4051-BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Simon P Hogan1. Mary H. Weiser Food Allergy Center, Department of Pathology, University of Michigan 4051-BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
University of Michigan–Ann Arbor · US

Funding

SLC9A3 regulation of esophageal dilated intercellular spaces in EoE SubtypesR01AI140133 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOGAN, SIMON PATRICK · 2019 to 2022
$2.5M
Food Allergy and Goblet Cell Antigen PassagesR01AI112626 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOGAN, SIMON PATRICK, NEWBERRY, RODNEY D · 2015 to 2019
$2.4M
Pro-Type 2 Goblet Cell Antigen Passages in Food Sensitization and ReactivityR37AI112626 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMON Patrick HOGAN, Rodney D Newberry · 2023 to 2026
$2.2M
Intestinal epithelial immunological responses and food allergen samplingR21AI138177 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOGAN, SIMON PATRICK · 2019 to 2020
$429k
NIAID NIH HHS R01 AI112626NIAID NIH HHS R01 AI140133NIAID NIH HHS R21 AI138177NIAID NIH HHS R37 AI112626
6 · The paper itself

Abstract

Food allergens are innocuous proteins that promote tolerogenic adaptive immune responses in healthy individuals yet in other individuals induce an allergic adaptive immune response characterized by the presence of antigen-specific immunoglobulin E and type-2 immune cells. The cellular and molecular processes that determine a tolerogenic versus non-tolerogenic immune response to dietary antigens are not fully elucidated. Recently, there have been advances in the identification of roles for microbial communities and anatomical sites of dietary antigen exposure and presentation that have provided new insights into the key regulatory steps in the tolerogenic versus non-tolerogenic decision-making processes. Herein, we will review and discuss recent findings in cellular and molecular processes underlying food sensitization and tolerance, immunological processes underlying severity of food-induced anaphylaxis, and insights obtained from immunotherapy trials.

Indexed as

AnaphylaxisFood HypersensitivityMicrobiotaAllergensHumansImmune ToleranceAllergensAllergic sensitizationAnaphylaxisAntigen samplingClinical trialsFood allergyIL-9 producing mucosal mast cellsMicrobiotaOral immunotherapyOral tolerancesecretory epithelial cell antigen passagesType-2 immune responses

Identifiers

PMID32789004
PMCPMC7401090
OpenAlexW3046536729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.