Evidence map›Paper›PMID 32788926›Full record

ArticleCardiovascular therapeutics2020

Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4

Kun-Peng Li, Hai-Yan Zhang, Xiao-Dong Xu, Ming-Yang, Tie-Jun Li, Shu-Tian Song

Open access · goldAbstract read
In one paragraph

Article in Cardiovascular therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kun-Peng LiDepartment of Cardiothoracic Surgery, The Cangzhou Central Hospital, Hebei Province 061001, China.
Hai-Yan ZhangDepartment of Nursing, Cangzhou Medical College, Hebei Province 061001, China.
Xiao-Dong XuDepartment of Medicine, Cangzhou Medical College, Hebei Province 061001, China.
Ming-YangDepartment of Cardiothoracic Surgery, The Cangzhou Central Hospital, Hebei Province 061001, China.
Tie-Jun LiDepartment of Anesthesiology, Cangzhou Central Hospital, Hebei Province 061001, China.
Shu-Tian SongDepartment of Cardiothoracic Surgery, The Cangzhou Central Hospital, Hebei Province 061001, China.ORCID https://orcid.org/0000-0003-0797-2745
Cangzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation plays a major role in the development of myocardial ischemia-reperfusion (IR) injury. Recombinant human brain natriuretic peptide (rhBNP), a man-made version of a peptide that is elevated in heart failure, exhibits anti-inflammatory effects in various tissues. However, its role in myocardial IR injury remains unclear. In this study, we demonstrate that treatment with rhBNP provided protection for mice against myocardial IR injury as manifested by reduced infarct size and well-preserved myocardial, attenuated inflammatory infiltration and CD4

Indexed as

AnimalsAnti-Inflammatory AgentsCD4-Positive T-LymphocytesCell ProliferationCytokinesDisease Models, AnimalHumansJurkat CellsMice, Inbred C57BLMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumNatriuretic Peptide, BrainPhosphatidylinositol 3-KinasePhosphorylationProto-Oncogene Proteins c-aktAnti-Inflammatory AgentsCytokinesMTOR protein, humanNatriuretic Peptide, BrainPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktRecombinant ProteinsTOR Serine-Threonine Kinases

Identifiers

PMID32788926
PMCPMC7330653
OpenAlexW3037929327

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.