Evidence map›Paper›PMID 32788870›Full record

ArticleInternational journal of medical sciences2020

Epigallocatechin-3-gallate preconditioned Adipose-derived Stem Cells confer Neuroprotection in aging rat brain.

Dennis Jine-Yuan Hsieh, Lawrence Marte, Wei-Wen Kuo, Da-Tong Ju, William Shao-Tsu Chen, Chia-Hua Kuo, Cecilia Hsuan Day, B Mahalakshmi, Po-Hsiang Liao, Chih-Yang Huang

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Dennis Jine-Yuan HsiehSchool of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 402, Taiwan.
Lawrence MarteDepartment of Healthcare Administration, Asia University, Taichung, 413, Taiwan.
Wei-Wen KuoDepartment of Biological Science and Technology, China Medical University, 404, Taichung, Taiwan.
Da-Tong JuDepartment of Neurological Surgery,Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
William Shao-Tsu ChenDepartment of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Chia-Hua KuoDepartment of Sports Sciences, University of Taipei, Taipei, 111, Taiwan.
Cecilia Hsuan DayDepartment of Nursing, MeiHo University, Pingtung, 912, Taiwan.
B MahalakshmiInstitute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam.
Po-Hsiang LiaoDivision of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei, 235, Taiwan.
Chih-Yang HuangDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.
Asia University · TWChina Medical University Hospital · TWChung Shan Medical University Hospital · TWDuy Tan University · VNTri-Service General Hospital · TWTzu Chi Foundation · TWUniversity of Taipei · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is the most important current issue and is usually accompanied by complications, such as cardiovascular disorders and neurodegenerative diseases, which are the leading causes of death worldwide and the second major cause of death in Taiwan. In this study, we have investigated the protective effect of adipose-derived mesenchymal stem cells (ADSCs) and the role of epigallocatechin gallate (EGCG) in enhancing this effect in aging cerebral cortex of rats. Further, we attempted to elucidate the molecular mechanism through which EGCG influences the protective effects of ADSC. ADSCs, co-cultured with EGCG, were injected into 20-month-old Wistar rats. Hematoxylin and eosin staining of the cerebral cortex revealed noticeable neurogenic activity and visible improvements in the integrity of the pre-frontal cortex tissue, compared to that in rats treated with ADSCs alone. Western blot analysis confirmed that ADSC, co-cultured with EGCG, enhanced cell survival via the p-Akt pathway and improved mitochondrial biogenesis via the SIRT-1 pathway. Moreover, it increased the available brain-derived neurotrophic factor to a higher degree than that in the ADSC group. Furthermore, western blotting showed that EGCG improved the antioxidant activity of the ADSCs in the cortex tissues via the Nrf-2 and HO-1 pathway. Based on these findings, we propose that this variation in stem cell treatment may facilitate functional recovery and enhanced neuroprotection in aged brains.

Indexed as

AdipocytesAgingAnimalsCatechinCells, CulturedCerebral CortexCoculture TechniquesHumansMesenchymal Stem CellsNeurogenesisNeuroprotective AgentsRatsSignal TransductionTaiwanCatechinepigallocatechin gallateNeuroprotective AgentsAdipose-derived mesenchymal stem cellsagingepigallocatechin gallateneuroprotection

Identifiers

PMID32788870
PMCPMC7415384
OpenAlexW3045464491

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.