ArticleNature2020
Structure of the essential inner membrane lipopolysaccharide-PbgA complex.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Fitness costs of mobilised colistin resistance gene 3 (mcr-3): systematic review, epidemiological study, and functional analysis.EBioMedicine · 2025Pooled it
- LpxC activity regulation: An emerging paradigm for controlling lipopolysaccharide synthesis.Trends in microbiology · 2026Article
- Protein-Protein Interactions Between Peptidoglycan, Lipopolysaccharide, and Phospholipid Biosynthesis Enzymes in Escherichia coli.Chembiochem : a European journal of chemical biology · 2026Article
- Lipopolysaccharide insertion and vesicle mediated turnover drive growth independent outer membrane adaptation in Escherichia coli.Nature communications · 2026Article
- Control of the committed step in lipopolysaccharide biosynthesis.The Journal of biological chemistry · 2026Review
- Acetylated mitochondrial MDH2 regulates CTR2 transcription to induce cuproptosis during Escherichia coli infection.Nature communications · 2026Article
- Article
- Crystal Structure of Periplasmic Domain of YejM fromJournal of microbiology and biotechnology · 2026Article
- Periplasmic crowding and peptidoglycan hydrolase activity as drivers of outer membrane vesiculation in Acinetobacter baumannii.Communications biology · 2026Article
- A potential role for acyl-phosphate in the coordination of phospholipid and lipopolysaccharide synthesis inbioRxiv : the preprint server for biology · 2026Article
- Exquisite specificity of Pks13 defines the essentiality of trehalose in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Coordinated Biosynthesis of Essential Cell Envelope Components: Lipopolysaccharide and Fatty Acids Requires LapD, Acyl Carrier Protein, and Fully Hexaacylated Lipid A.International journal of molecular sciences · 2025Article
- Comprehensive Genomic and Phenotypic Characterization ofMicroorganisms · 2025Article
- Identifying Modulators of the Post-Antibiotic Effect.ACS infectious diseases · 2025Article
- Novel bifunctional antibacterial peptides mediated by a covalent conjugation strategy combat priority multidrug-resistant gram-negative pathogens through dual targets.The Journal of antibiotics · 2025Article
- Macromolecular crystallography and biology at the Linac Coherent Light Source.Journal of synchrotron radiation · 2025Article
- Rational Design of Natural Xanthones Against Gram-negative Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- PlsX and PlsY: Additional roles beyond glycerophospholipid synthesis in Gram-negative bacteria.mBio · 2024Article
- Membrane lipid homeostasis dually regulates conformational transition of phosphoethanolamine transferase EptA.Nature communications · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 4 institutions in 2 countries.
Thomas Clairfeuille *Structural Biology, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4763-8928
Kerry R Buchholz *Infectious Diseases, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9419-0076
Qingling LiMicrochemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA.
Erik VerschuerenMicrochemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA.
Peter LiuMicrochemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA.
Dewakar SangarajuDrug Metabolism & Pharmacokinetics, Genentech Inc., South San Francisco, CA, USA.
Summer ParkTranslational Immunology, Genentech Inc., South San Francisco, CA, USA.
Cameron L NolandStructural Biology, Genentech Inc., South San Francisco, CA, USA.
Kelly M StorekInfectious Diseases, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2289-0214
Nicholas N NickersonInfectious Diseases, Genentech Inc., South San Francisco, CA, USA.
Lynn MartinBioMolecular Resources, Genentech Inc., South San Francisco, CA, USA.
Trisha Dela VegaBioMolecular Resources, Genentech Inc., South San Francisco, CA, USA.
Anh MiuBiochemical & Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USA.
Janina ReederBioinformatics & Computational Biology, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6704-6754
Maria Ruiz-GonzalezDiscovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA.
Danielle SwemInfectious Diseases, Genentech Inc., South San Francisco, CA, USA.
Guanghui HanMicrochemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9893-9168
Daniel P DePonteLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Mark S HunterLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID http://orcid.org/0000-0002-0110-7075
Cornelius GatiBioscience Division, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID http://orcid.org/0000-0003-3693-7009
Sheerin Shahidi-LathamDrug Metabolism & Pharmacokinetics, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2773-4325
Min XuTranslational Immunology, Genentech Inc., South San Francisco, CA, USA.
Nicholas SkeltonDiscovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA.
Benjamin D SellersDiscovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4194-1240
Elizabeth SkippingtonBioinformatics & Computational Biology, Genentech Inc., South San Francisco, CA, USA.
Wendy SandovalMicrochemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA.
Emily J HananDiscovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA. hanan.emily@gene.com.ORCID http://orcid.org/0000-0001-7681-9424
Jian PayandehStructural Biology, Genentech Inc., South San Francisco, CA, USA. payandeh.jian@gene.com.ORCID http://orcid.org/0000-0002-4015-9716
Steven T RutherfordInfectious Diseases, Genentech Inc., South San Francisco, CA, USA. rutherford.steven@gene.com.ORCID http://orcid.org/0000-0002-4758-4248
SLAC National Accelerator Laboratory · USGene Therapy Laboratory · FRSunesis (United States) · USGenVec · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it is responsible for barrier function
Indexed as
AmidohydrolasesAmino Acid MotifsBacterial Outer MembraneBinding SitesCell MembraneEnzyme StabilityEscherichia coliEscherichia coli ProteinsGenes, EssentialHydrolasesLipid ALipopolysaccharidesMicrobial Sensitivity TestsMicrobial ViabilityModels, MolecularPeptide FragmentsAmidohydrolasesEscherichia coli ProteinsHydrolasesLipid ALipopolysaccharidesPeptide FragmentsUDP-3-O-acyl-N-acetylglucosamine deacetylaseYejM protein, E coli
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.