ArticleNature communications2020
Neural mechanisms underlying the effects of physical fatigue on effort-based choice.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The neural basis of cost-benefit trade-offs in effort investment: a quantitative activation likelihood estimation meta-analysis.Cognitive, affective & behavioral neuroscience · 2026Pooled it
- An experimental study on the effect of symptom expectations on mental fatigue and motivation in people with primary biliary cholangitis.Scientific reports · 2025Trial
- Post-stroke rehabilitative mechanisms in individualized fatigue level-controlled treadmill training in rats.Neural regeneration research · 2026Article
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- Increased exertion variability is linked to disruptions in effort assessment in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Examining effects of effort and reward magnitude on effort-cost decision-making in people with major depressive disorder.Cognitive, affective & behavioral neuroscience · 2026Article
- Physical and cognitive contributions to fatigue perception: The interplay between local muscle fatigue and sensory prediction error.iScience · 2026Article
- Poststroke Fatigue: An Overlooked Barrier to Functional Recovery.Journal of the American Heart Association · 2026Article
- Shared and distinct features of common effort-based decision-making paradigms and their relation to brain structure and neuropsychiatric conditions: An integrated narrative review.Cognitive, affective & behavioral neuroscience · 2026Review
- Computational signatures of exertion and rest underlie moment-to-moment dynamics of subjective perceptions of effort and fatigue.Cognitive, affective & behavioral neuroscience · 2026Article
- Self-Organizing Recruitment of Compensatory Cortical Areas Post-Stroke Can Maximize Residual Motor Performance.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Article
- Predictive processes linking sense of agency and fatigue: a novel allostatic framework.Frontiers in psychology · 2026Article
- Article
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.medRxiv : the preprint server for health sciences · 2025Article
- A behavioural and neurobiological assessment of effort-based decision-making in cannabis use disorder: An initial/preliminary investigation.Cognitive, affective & behavioral neuroscience · 2025Article
- Depression Levels Are Associated with Reduced Capacity to Learn to Actively Avoid Aversive Events in Young Adults.eNeuro · 2025Article
- The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Increased Sensitivity to Effort and Perception of Effort in People with Schizophrenia.Schizophrenia bulletin · 2025Article
- Neural mechanisms underlying the effects of cognitive fatigue on physical effort-based choice.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Physical fatigue crucially influences our decisions to partake in effortful action. However, there is a limited understanding of how fatigue impacts effort-based decision-making at the level of brain and behavior. We use functional magnetic resonance imaging to record markers of brain activity while human participants engage in uncertain choices for prospective physical effort, before and after bouts of exertion. Using computational modeling of choice behavior we find that fatiguing exertions cause participants to increase their subjective cost of effort, compared to a baseline/rested state. We describe a mechanism by which signals related to motor cortical state in premotor cortex influence effort value computations, instantiated by insula, thereby increasing an individual's subjective valuation of prospective physical effort while fatigued. Our findings provide a neurobiological account of how information about bodily state modulates decisions to engage in physical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.