Primary Position Upbeat Nystagmus with Low Serum Vitamin B12.

Haruka Ouchi, Kazuo Ishikawa, Kana Inoue, Ken Shibano, Kenju Hara

Open access · diamondAbstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 89% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Haruka OuchiDepartment of Neurology, Japanese Red Cross Akita Hospital, Japan.

Kazuo IshikawaDepartment of Otolaryngology, Dizziness Center, Japanese Red Cross Akita Hospital, Japan.

Kana InoueDepartment of Neurology, Japanese Red Cross Akita Hospital, Japan.

Ken ShibanoDepartment of Neurology, Japanese Red Cross Akita Hospital, Japan.

Kenju HaraDepartment of Neurology, Japanese Red Cross Akita Hospital, Japan.

Akita Red Cross Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 38-year-old man presented with primary position upbeat nystagmus accompanied by peripheral neuropathy. The serum vitamin B12 level was low along with high plasma homocysteine level, indicating vitamin B12 deficiency. Cyanocobalamin supplementation showed partial clinical and electrophysiological improvement. Although brain magnetic resonance imaging did not show any abnormal intensity lesions, the electrophysiological findings suggested that a pontomedullary medial lesion was responsible for the upbeat nystagmus. To our knowledge, this is the first case of upbeat nystagmus with low serum vitamin B12. Physicians need to recognize the possibility of vitamin B12 deficiency as a cause of upbeat nystagmus.

Indexed as

Nystagmus, PathologicVitamin B 12 DeficiencyAdultHumansMagnetic Resonance ImagingMaleVitamin B 12Vitamin B 12electronystagmographysuperior vestibular nucleusupbeat nystagmusventral tegmental tractvitamin B12 deficiency

Identifiers

PMID32788546

DOI10.2169/internalmedicine.5241-20

PMCPMC7807101

OpenAlexW3048557685

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.