Evidence map›Paper›PMID 32788384›Full record

ArticlemBio2020

Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence.

Katja Schaefer, Jeanette Wagener, Ryan M Ames, Stella Christou, Donna M MacCallum, Steven Bates, Neil A R Gow

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. mBio · 2026
    Article
  2. Article
  3. Article
  4. Arginine inhibits cross-kingdom interactions and synergistic cariogenicity betweenFrontiers in cellular and infection microbiology · 2025
    Article
  5. Article
  6. Microorganisms · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Katja SchaeferMedical Research Council Centre for Medical Mycology at The University of Exeter, University of Exeter, Exeter, United Kingdom.ORCID 0000-0002-5315-3962
Jeanette WagenerThe Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.ORCID 0000-0002-7227-4348
Ryan M AmesDepartment of Biosciences, University of Exeter, Exeter, United Kingdom.ORCID 0000-0002-1432-5629
Stella ChristouThe Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.ORCID 0000-0002-8287-788X
Donna M MacCallumThe Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.ORCID 0000-0003-4833-0378
Steven BatesMedical Research Council Centre for Medical Mycology at The University of Exeter, University of Exeter, Exeter, United Kingdom s.bates@exeter.ac.uk n.gow@exeter.ac.uk.ORCID 0000-0003-0489-5705
Neil A R GowMedical Research Council Centre for Medical Mycology at The University of Exeter, University of Exeter, Exeter, United Kingdom s.bates@exeter.ac.uk n.gow@exeter.ac.uk.ORCID 0000-0002-2776-5850
University of Aberdeen · GBUniversity of Exeter · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/N006364/1Medical Research Council MR/N006364/2Wellcome TrustWellcome Trust 097377/Z11/ZWellcome Trust 101873/Z/13/ZWellcome Trust 200208/A/15/Z
6 · The paper itself

Abstract

Amino acid metabolism is crucial for fungal growth and development. Ureohydrolases produce amines when acting on l-arginine, agmatine, and guanidinobutyrate (GB), and these enzymes generate ornithine (by arginase), putrescine (by agmatinase), or GABA (by 4-guanidinobutyrase or GBase).

Indexed as

AgmatineAmino AcidsAnimalsArginaseArginineCandida albicansCloning, MolecularFemaleFungal ProteinsLarvaMetabolic Networks and PathwaysMiceMice, Inbred BALB CMothsRAW 264.7 CellsUreohydrolasesagmatinaseAgmatineAmino AcidsArginaseArginineFungal ProteinsguanidinobutyraseUreohydrolasesagmatinasearginaseCandidaCandida albicansguanidinobutyraseimmunitymacrophagesmorphogenesis

Identifiers

PMID32788384
PMCPMC7439472
OpenAlexW3048747344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.