Evidence map›Paper›PMID 32788383›Full record

ArticlemBio2020

A Genome-Wide CRISPR/Cas9 Screen Reveals that Riboflavin Regulates Hydrogen Peroxide Entry into HAP1 Cells.

Tamutenda Chidawanyika, Kenneth M K Mark, Surachai Supattapone

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Carotenoid modifying enzymes in metazoans.Methods in enzymology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tamutenda ChidawanyikaDepartment of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Kenneth M K MarkDepartment of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Surachai SupattaponeDepartment of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA supattapone@dartmouth.edu.
Dartmouth College · US

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Structural Mechanism of Mammalian Prion InfectivityR01NS118796 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI, ZILM, KURT WILLIAM · 2020 to 2024
$2.8M
Novel Therapeutic Strategies Targeting Malleability of Wild-Type and Mutant PrionsR01NS117276 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI · 2020 to 2025
$2.4M
Dissecting the Mechanism of Prion Formation with a Permissive HostR01NS102301 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI · 2018 to 2021
$2.2M
Structural Mechanism of Mammalian Prion InfectivityR56NS094576 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI, ZILM, KURT WILLIAM · 2017 to 2017
$567k
Long-Term Safety, Efficacy, and Mechanism of PERK Inhibition Therapy for Prion DiseaseR21NS095763 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI · 2016 to 2017
$446k
Combination Chemotherapy for Treatment of Prion DiseaseR21NS099928 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI · 2017 to 2018
$446k
NIGMS NIH HHS P20 GM113132NINDS NIH HHS R01 NS102301NINDS NIH HHS R01 NS117276NINDS NIH HHS R01 NS118796NINDS NIH HHS R21 NS095763NINDS NIH HHS R21 NS099928NINDS NIH HHS R56 NS094576
6 · The paper itself

Abstract

Extracellular hydrogen peroxide can induce oxidative stress, which can cause cell death if unresolved. However, the cellular mediators of H

Indexed as

CRISPR-Cas SystemsGene Expression RegulationBiological TransportCell LineCell SurvivalHEK293 CellsHumansHydrogen PeroxideLeukocytesOxidative StressReceptors, G-Protein-CoupledRiboflavinHydrogen PeroxideReceptors, G-Protein-CoupledRiboflavinSLC52A2 protein, humanaquaporinhydrogen peroxideKEAP1membrane transportoxidative stressP450 oxidoreductaseretinol saturaseriboflavinriboflavin transporter

Identifiers

PMID32788383
PMCPMC7439486
OpenAlexW3048874608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.