Evidence map›Paper›PMID 32788367›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Evasion of MAIT cell recognition by the African

Lorena Preciado-Llanes, Anna Aulicino, Rocío Canals, Patrick J Moynihan, Xiaojun Zhu, Ndaru Jambo, Tonney S Nyirenda, Innocent Kadwala, Ana Sousa Gerós, Siân V Owen and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Avoidance of MAIT cells is an essential determinant ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Persistence of non-typhoidalFrontiers in microbiology · 2026
    Review
  5. Article
  6. MAIT cells: Conserved watchers on the wall.The Journal of experimental medicine · 2025
    Review
  7. Review
  8. Article
  9. microLife · 2024
    Article
  10. Review
  11. Article
  12. The Challenge Non-TyphoidalWellcome open research · 2023
    Article
  13. The intracellular pathogenLife science alliance · 2022
    Article
  14. Mucosa-Associated Invariant T Cell Hypersensitivity toJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Frontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Lorena Preciado-LlanesMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, United Kingdom; mariolina.salio@imm.ox.ac.uk lorena.preciado-llanes@ndm.ox.ac.uk.ORCID 0000-0001-5120-3578
Anna AulicinoMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, United Kingdom.ORCID 0000-0002-3407-2796
Rocío CanalsInstitute of Integrative Biology, University of Liverpool, L69 7ZB Liverpool, United Kingdom.ORCID 0000-0001-7079-7690
Patrick J MoynihanInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, B11 2TT Birmingham, United Kingdom.ORCID 0000-0003-4182-6223
Xiaojun ZhuInstitute of Integrative Biology, University of Liverpool, L69 7ZB Liverpool, United Kingdom.ORCID 0000-0002-1478-8500
Ndaru JamboMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre 3, Malawi, Central Africa.
Tonney S NyirendaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre 3, Malawi, Central Africa.
Innocent KadwalaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre 3, Malawi, Central Africa.
Ana Sousa GerósMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, United Kingdom.
Siân V OwenDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-5330-3177
Kondwani C JamboMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre 3, Malawi, Central Africa.ORCID 0000-0002-3195-2210
Benjamin KumwendaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre 3, Malawi, Central Africa.
Natacha VeerapenInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, B11 2TT Birmingham, United Kingdom.
Gurdyal S BesraInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, B11 2TT Birmingham, United Kingdom.ORCID 0000-0002-5605-0395
Melita A GordonMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre 3, Malawi, Central Africa.ORCID 0000-0002-0629-0884
Jay C D HintonInstitute of Integrative Biology, University of Liverpool, L69 7ZB Liverpool, United Kingdom.ORCID 0000-0003-2671-6026
Giorgio NapolitaniMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, United Kingdom.
Mariolina SalioMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, United Kingdom; mariolina.salio@imm.ox.ac.uk lorena.preciado-llanes@ndm.ox.ac.uk.ORCID 0000-0002-4821-3801
Alison SimmonsMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, United Kingdom.ORCID 0000-0003-3454-0710
University of Liverpool · GBUniversity of Oxford · GBUniversity of Birmingham · GBHarvard University · US

Funding

Biotechnology and Biological Sciences Research Council BB/S010122/1Department of HealthMedical Research Council MC_PC_MR/S025952/1Medical Research Council MC_UU_00008/7Medical Research Council MC_UU_12010/7Medical Research Council MR/S000542/1Medical Research Council MR/S036377/1Wellcome TrustWellcome Trust 106914/Z/15/Z
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacteria that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role for MAIT cells in antimicrobial defense. However, proposed protective roles of MAIT cells in human infections remain unproven and clinical conditions associated with selective absence of MAIT cells have not been identified. We report that typhoidal and nontyphoidal

Indexed as

Africa South of the SaharaAnti-Bacterial AgentsDiarrheaHumansImmune EvasionMucosal-Associated Invariant T CellsSalmonella InfectionsSalmonella typhimuriumAnti-Bacterial Agentsinvasive nontyphoidal SalmonellaMR1Salmonella Typhimuriumsequence type 313ST313

Identifiers

PMID32788367
PMCPMC7456131
OpenAlexW3041532749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.