Evidence map›Paper›PMID 32788352›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage.

Kim Krighaar Rasmussen, Andrés Palencia, Anders K Varming, Habiba El-Wali, Elisabetta Boeri Erba, Martin Blackledge, Karin Hammer, Torsten Herrmann, Mogens Kilstrup, Leila Lo Leggio and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Characterization of a novel phage-plasmid vB_EcoM_ED targeting multidrug-resistant Escherichia coli isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. CI:Mor interactions in the lysogeny switches ofMicrobiome research reports · 2024
    Article
  8. Review
  9. Article
  10. Influence ofViruses · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kim Krighaar RasmussenDepartment of Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark.ORCID 0000-0003-1589-5663
Andrés PalenciaInstitute for Advanced Biosciences, Structural Biology of Novel Drug Targets in Human Diseases, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, F-38000 Grenoble, France.ORCID 0000-0002-1805-319X
Anders K VarmingDepartment of Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark.ORCID 0000-0001-6865-990X
Habiba El-WaliMetabolic Signaling and Regulation, Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Elisabetta Boeri ErbaUniversité Grenoble Alpes, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Structurale, F-38000 Grenoble, France.ORCID 0000-0002-5910-4707
Martin BlackledgeUniversité Grenoble Alpes, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Structurale, F-38000 Grenoble, France.
Karin HammerMetabolic Signaling and Regulation, Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark.ORCID 0000-0002-6250-8067
Torsten HerrmannUniversité Grenoble Alpes, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Structurale, F-38000 Grenoble, France.
Mogens KilstrupMetabolic Signaling and Regulation, Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Leila Lo LeggioDepartment of Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark; leila@chem.ku.dk malene.ringkjobing-jensen@ibs.fr.ORCID 0000-0002-5135-0882
Malene Ringkjøbing JensenUniversité Grenoble Alpes, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Structurale, F-38000 Grenoble, France leila@chem.ku.dk malene.ringkjobing-jensen@ibs.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temperate bacteriophages can enter one of two life cycles following infection of a sensitive host: the lysogenic or the lytic life cycle. The choice between the two alternative life cycles is dependent upon a tight regulation of promoters and their cognate regulatory proteins within the phage genome. We investigated the genetic switch of TP901-1, a bacteriophage of

Indexed as

LysogenyBacteriophagesGenome, BacterialHost-Pathogen InteractionsKineticsLactococcus lactisMolecular Dynamics SimulationOperator Regions, GeneticProtein ConformationRepressor ProteinsViral Regulatory and Accessory Proteinsphage repressor proteinsRepressor ProteinsViral Regulatory and Accessory Proteinsgenetic switchNMRprotein dynamicstemperate bacteriophageX-ray crystallography

Identifiers

PMID32788352
PMCPMC7456139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.