ArticleScience signaling2020
Oxidative cross-linking of fibronectin confers protease resistance and inhibits cellular migration.
Open access · greenAbstract read
In one paragraph
Article in Science signaling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- MMP3C v2: a network-based framework decoding metabolic plasticity in rheumatoid arthritis, enabling accurate diagnosis and uncovering cell-type-specific metabolic rewiring.Briefings in bioinformatics · 2026Article
- Myeloperoxidase promotes fibrosis by inhibiting cathepsin K to bias the lung toward ECM accumulation.bioRxiv : the preprint server for biology · 2026Article
- Local photocrosslinking of native tissue matrix regulates lung epithelial cell mechanosensing and function.Nature materials · 2025Article
- Mechanosensing Pathways in the Progression of Pulmonary Fibrosis.Current opinion in biomedical engineering · 2025Article
- Silk Fibroin-Based Hydrogels Supplemented with Decellularized Extracellular Matrix and Gelatin Facilitate 3D Bioprinting for Meniscus Tissue Engineering.Macromolecular bioscience · 2025Article
- Empowering canonical biochemicals with cross-linked novelty: Recursions in applications of protein cross-links.Proteins · 2025Review
- Premetastatic niche mechanics and organotropism in breast cancer.npj biological physics and mechanics · 2025Review
- Endoplasmic Reticulum Oxidative Stress Promotes Glutathione-Dependent Oxidation of Collagen-1A1 and Promotes Lung Fibroblast Activation.American journal of respiratory cell and molecular biology · 2024Article
- Local photo-crosslinking of native tissue matrix regulates cell function.bioRxiv : the preprint server for biology · 2024Article
- Large-Scale Qualitative and Quantitative Assessment of Dityrosine Crosslinking Omics in Response to Endogenous and Exogenous Hydrogen Peroxide inAntioxidants (Basel, Switzerland) · 2023Article
- Di-Tyrosine Crosslinking andAntioxidants (Basel, Switzerland) · 2021Article
- Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non-Cell-Adhesive Materials.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice.The Journal of experimental medicine · 2021Article
- Deletion of bone marrow myeloperoxidase attenuates chronic kidney disease accelerated atherosclerosis.The Journal of biological chemistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Morgan L LocyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.ORCID 0000-0002-3812-5867
Sunad RangarajanDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.ORCID 0000-0001-5313-4828
Sufen YangDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.
Mark R JohnsonDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.ORCID 0000-0003-0742-6728
Karen BernardDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.
Ashish KurundkarDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.
Nathaniel B BoneDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.
Jaroslaw W ZmijewskiDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.
Jaeman ByunDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Subramaniam PennathurDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3628-6883
Yong ZhouDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.
Victor J ThannickalDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA. vthannickal@uabmc.edu.ORCID 0000-0003-4266-8677
University of Alabama at Birmingham · USUniversity of Michigan · US
Funding
Therapeutic Targeting of the Myofibroblast in Fibrotic Lung DiseaseP01HL114470 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THANNICKAL, VICTOR J. · 2013 to 2022
$17.8MAMPK in the Development and Resolution of Lung FibrosisR01HL139617 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Victor J. Thannickal, Jaroslaw Waldemar Zmijewski · 2019 to 2026
$4.4MMyofibroblast Senescence in Pulmonary FibrosisR01AG046210 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THANNICKAL, VICTOR J. · 2014 to 2018
$1.6MMitochondrial UCP2 in Age-Related Lung FibrosisK08HL135399 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI RANGARAJAN, SUNAD · 2017 to 2021
$841kProtein o,o'-Dityrosine Cross-linking in Lung Injury and Wound HealingF30HL136195 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOCY, MORGAN LEE · 2017 to 2020
$141kBLRD VA I01 BX003056NHLBI NIH HHS F30 HL136195NHLBI NIH HHS K08 HL135399NHLBI NIH HHS P01 HL114470NHLBI NIH HHS R01 HL139617NIA NIH HHS R01 AG046210
Abstract
The oxidation of tyrosine residues to generate
Indexed as
A549 CellsAnimalsCell LineCell MovementCells, CulturedCross-Linking ReagentsExtracellular MatrixFemaleFibronectinsHumansMice, Inbred C57BLMice, KnockoutMyofibroblastsNeutrophilsOxidation-ReductionOxidative StressCross-Linking ReagentsdityrosineFibronectinsPeptide HydrolasesPeroxidaseTransforming Growth Factor beta1Tyrosine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.