Evidence map›Paper›PMID 32788245›Full record

ArticleNeurology2020

Risk factors for possible REM sleep behavior disorders: A community-based study in Beijing.

Hui Zhang, Zhuqin Gu, Chun Yao, Yanning Cai, Yuan Li, Wei Mao, Erhe Xu, Ronald B Postuma, Piu Chan

Abstract read
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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  7. Review
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  9. High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  10. Article
  11. Article
  12. Research progress in rapid eye movement sleep behavior disorder.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui ZhangFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada.
Zhuqin GuFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada.
Chun YaoFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada.
Yanning CaiFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada.
Yuan LiFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada.
Wei MaoFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada.
Erhe XuFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada.
Ronald B PostumaFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada.
Piu ChanFrom the Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders (H.Z.), Department of Neurobiology, Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Y.C.), and Department of Neurology (Y.L., W.M., E.X.), Xuanwu Hospital of Capital Medical University (P.C.); Key Laboratory of Ministry of Education for Neurodegenerative Diseases (Z.G.) and Department of Neurology, Neurobiology, and Geriatrics, National Clinical Research Center for Geriatric Disorders, Clinical and Research Center for Parkinson's Disease (P.C.), Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China; Integrated Program in Neuroscience (C.Y.), McGill University; and Department of Neurology (R.B.P.), Montreal General Hospital, Canada. pbchan@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the risk factors for idiopathic REM sleep behavior disorder (RBD) in a community population in Beijing.

methodsParticipants aged 55 years and above were recruited from the Beijing Longitudinal Study on Aging II cohort. We identified individuals with possible RBD (pRBD) using the validated RBD Questionnaire-Hong Kong in 2010. A series of environmental, lifestyle, and other potential risk factors were assessed via standardized questionnaires in 2009. Multivariable logistic regression analysis was performed to investigate the association between the studied factors and pRBD.

resultsOf 7,225 participants who were free of parkinsonism and dementia, 219 (3.0%) individuals were considered as having pRBD. Participants with pRBD reported more nonmotor and motor symptoms of Parkinson disease (PD) with adjusted odds ratios (ORs) ranging from 1.10 to 4.40. Participants with pRBD were more likely to report a family history of parkinsonism or dementia (OR 3.03, 95% confidence interval [CI] 1.23-7.46). There was a significant association between pRBD and self-reported hyperlipidemia (OR 1.51, 95% CI 1.09-2.10), ever smoking (OR 1.79, 95% CI 1.20-2.65), prior carbon monoxide (CO) poisoning (OR 2.30, 95% CI 1.39-3.83), and nonoccupational exposure to pesticides (OR 2.21, 95% CI 1.40-3.50).

conclusionOur study replicated previously reported associations between pRBD and hyperlipidemia, smoking, pesticide exposure, and several prodromal PD symptoms. We also found previously unreported links with a positive family history of parkinsonism or dementia and CO poisoning. Risk factor profiles for pRBD partially resemble those defined for PD, but also differ in distinct ways.

Indexed as

AgedBeijingFemaleHumansLife StyleLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisREM Sleep Behavior DisorderRisk Factors

Identifiers

PMID32788245
PMCPMC7713784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.