Evidence map›Paper›PMID 32788232›Full record

ArticleJournal of cell science2020

Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton.

Wenqing Zhou, Alan Y Hsu, Yueyang Wang, Ramizah Syahirah, Tianqi Wang, Jacob Jeffries, Xu Wang, Haroon Mohammad, Mohamed N Seleem, David Umulis and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Modeling of Charcot-Marie-Tooth disease in zebrafish.Frontiers in molecular neuroscience · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. The circadian neutrophil, inside-out.Journal of leukocyte biology · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Roles of mitochondria in neutrophils.Frontiers in immunology · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wenqing ZhouDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Alan Y HsuDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-5680-345X
Yueyang WangDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-5445-8186
Ramizah SyahirahDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Tianqi WangDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Jacob JeffriesDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Xu WangDepartment of Agricultural & Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.
Haroon MohammadDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.
Mohamed N SeleemDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.
David UmulisDepartment of Agricultural & Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.
Qing DengDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA deng67@purdue.edu.ORCID 0000-0002-9254-9951
Purdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Role of microRNAs in neutrophil migrationR35GM119787 · NIGMS · PURDUE UNIVERSITY · PI Qing Deng · 2016 to 2026
$4.9M
Systems Analysis of BMP Regulation in Developing Zebrafish EmbryosR01HD073156 · NICHD · PURDUE UNIVERSITY · PI UMULIS, DAVID MICHAEL · 2013 to 2017
$1.5M
Modeling and analysis of BMP-mediated Dorsal/Ventral patterning in zebrafish embryosR01GM132501 · NIGMS · PURDUE UNIVERSITY · PI UMULIS, DAVID MICHAEL · 2019 to 2022
$1.4M
BD Fortessa Flow Cytometer for Multi-User Shared FacilityS10OD020029 · OD · PURDUE UNIVERSITY · PI RATLIFF, TIMOTHY L. · 2015 to 2015
$412k
NCI NIH HHS P30 CA023168NICHD NIH HHS R01 HD073156NIGMS NIH HHS R01 GM132501NIGMS NIH HHS R35 GM119787NIH HHS S10 OD020029
6 · The paper itself

Abstract

Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial outer membrane protein Mitofusin 2 (MFN2) regulates neutrophil homeostasis and chemotaxis

Indexed as

NeutrophilsZebrafishActin CytoskeletonAdhesivesAnimalsCell MovementMiceAdhesivesActinChemotaxisLeukocyteMitochondriaRacZebrafish

Identifiers

PMID32788232
PMCPMC7491649
OpenAlexW3048817450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.