Evidence map›Paper›PMID 32788218›Full record

ArticleThe Journal of biological chemistry2020

Caspases from scleractinian coral show unique regulatory features.

Suman Shrestha, Jessica Tung, Robert D Grinshpon, Paul Swartz, Paul T Hamilton, Bradford Dimos, Laura Mydlarz, A Clay Clark

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Sequential unfolding mechanisms of monomeric caspases.bioRxiv : the preprint server for biology · 2023
    Article
  4. Article
  5. Evolution of the folding landscape of effector caspases.The Journal of biological chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Suman ShresthaDepartment of Biology, University of Texas at Arlington, Arlington, Texas, USA.
Jessica TungDepartment of Biology, University of Texas at Arlington, Arlington, Texas, USA.
Robert D GrinshponDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina, USA.
Paul SwartzDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina, USA.
Paul T HamiltonDepartment of Plant and Microbial Biology, North Carolina State University, Raleigh, North Carolina, USA.
Bradford DimosDepartment of Biology, University of Texas at Arlington, Arlington, Texas, USA.
Laura MydlarzDepartment of Biology, University of Texas at Arlington, Arlington, Texas, USA.
A Clay ClarkDepartment of Biology, University of Texas at Arlington, Arlington, Texas, USA. Electronic address: clay.clark@uta.edu.
The University of Texas at Arlington · USNorth Carolina State University · US

Funding

Evolution of effector caspase conformational landscapesR01GM127654 · NIGMS · UNIVERSITY OF TEXAS ARLINGTON · PI CLARK, ALLAN CLAY · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM127654
6 · The paper itself

Abstract

Coral reefs are experiencing precipitous declines around the globe with coral diseases and temperature-induced bleaching being primary drivers of these declines. Regulation of apoptotic cell death is an important component in the coral stress response. Although cnidaria are known to contain complex apoptotic signaling pathways, similar to those in vertebrates, the mechanisms leading to cell death are largely unexplored. We identified and characterized two caspases each from

Indexed as

Amino Acid SequenceAnimalsAnthozoaApoptosisCaspasesCoral ReefsCrystallography, X-RayEnzyme ActivationHumansModels, MolecularProtein ConformationProtein DomainsSequence AlignmentSubstrate SpecificityCaspasesallosteric regulationapoptosisCARD-caspasecaspasecoral apoptosiscoral immunitycysteine proteasefunctional divergencesubstrate selectionsubstrate specificity

Identifiers

PMID32788218
PMCPMC7586219
OpenAlexW3048551549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.