Evidence map›Paper›PMID 32788215›Full record

ArticleThe Journal of biological chemistry2020

The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal.

Khumoekae Richard, Cole Schonhofer, Leila B Giron, Jocelyn Rivera-Ortiz, Silven Read, Toshitha Kannan, Natalie N Kinloch, Aniqa Shahid, Ruth Feilcke, Simone Wappler and 10 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Traditional Medicine Extracts ofInternational journal of molecular sciences · 2026
    Article
  2. mBio · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Cheminformatics-Based Study Identifies Potential Ebola VP40 Inhibitors.International journal of molecular sciences · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Khumoekae RichardFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Cole SchonhoferFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Leila B GironWistar Institute, Philadelphia, Pennsylvania, USA.
Jocelyn Rivera-OrtizWistar Institute, Philadelphia, Pennsylvania, USA.
Silven ReadFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Toshitha KannanWistar Institute, Philadelphia, Pennsylvania, USA.
Natalie N KinlochFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Aniqa ShahidFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Ruth FeilckeInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Simone WapplerInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Peter ImmingInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Marianne HarrisBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Zabrina L BrummeFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Mark A BrockmanFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0001-6432-1426
Karam MounzerJonathan Lax Immune Disorders Treatment Center, Philadelphia Field Initiating Group for HIV-1 Trials, Philadelphia, Pennsylvania, USA.
Andrew V KossenkovWistar Institute, Philadelphia, Pennsylvania, USA.
Mohamed Abdel-MohsenWistar Institute, Philadelphia, Pennsylvania, USA.
Kerstin Andrae-MarobelaDepartment of Biological Sciences, University of Botswana, Gaborone, Botswana.
Luis J MontanerWistar Institute, Philadelphia, Pennsylvania, USA.
Ian TietjenFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada itietjen@wistar.org.
Simon Fraser University · CAThe Wistar Institute · USMartin Luther University Halle-Wittenberg · DEAIDS Vancouver · CAPhiladelphia Fight · USUniversity of Botswana · BW

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Role of Intestinal Barrier Integrity in Modulating the Host Glycome During COVID-19R01DK123733 · NIDDK · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, KESHAVARZIAN, ALI · 2020 to 2024
$4.5M
Host Glycomic Modulation of HIV-associated Neuro-inflammation During Viral SuppressionR01NS117458 · NINDS · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, NDHLOVU, LISHOMWA C · 2020 to 2023
$3.4M
Sialic Acid Modulation of HIV-associated Chronic InflammagingR01AG062383 · NIA · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2019 to 2023
$3.0M
Exploring Cell-free Glycomic Interactions in HIV-associated Neurological DisordersR21NS106970 · NINDS · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, NDHLOVU, LISHOMWA C · 2017 to 2018
$507k
Role of Host Glycosylation in the Galectin-9-Mediated Reversal of HIV LatencyR21AI129636 · NIAID · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2017 to 2018
$496k
Host Glycomic Determinants of HIV Persistence in vivoR21AI143385 · NIAID · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2019 to 2020
$491k
CIHR PJT-153057CIHR PJT-159625NIAID NIH HHS P30 AI045008NIAID NIH HHS R21 AI129636NIAID NIH HHS R21 AI143385NIAID NIH HHS UM1 AI126620NIA NIH HHS R01 AG062383NIDDK NIH HHS R01 DK123733NINDS NIH HHS R01 NS117458NINDS NIH HHS R21 NS106970Wellcome TrustWellcome Trust 107752/Z/15/Z
6 · The paper itself

Abstract

A sterilizing or functional cure for HIV is currently precluded by resting CD4

Indexed as

AnthracenesAnthralinAnthronesDrug Evaluation, PreclinicalHIV-1HIV InfectionsHumansJurkat CellsVirus LatencyAnthracenesAnthralinAnthronesknipholone anthronedrug discoverydrug-drug synergyhistone deacetylase (HDAC)histone deacetylase inhibitor (HDAC inhibitor) (HDI)human immunodeficiency virus (HIV)latency reversalmolecular pharmacologynatural productprotein kinase C (PKC)viral reservoirs

Identifiers

PMID32788215
PMCPMC7549037
OpenAlexW3048716765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.