ArticleDrug metabolism and disposition: the biological fate of chemicals2020
Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Drug metabolism and disposition: the biological fate of chemicals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05157672 (Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon), which is not on this map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon
Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Combinatorial Treatment with Chlorogenic Acid and Cinnamaldehyde Disrupts Intracellular pH and Metabolic Transport in Breast Cancer Cells.Molecules (Basel, Switzerland) · 2026Article
- Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio.Clinical pharmacology and therapeutics · 2026Article
- Enzyme-substrate-inactivator complex formation can impact time-dependent inhibition kinetics.Drug metabolism and disposition: the biological fate of chemicals · 2026Article
- In Silico ADME Methods Used in the Evaluation of Natural Products.Pharmaceutics · 2025Review
- Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy.Military Medical Research · 2024Review
- The role and mechanism of cinnamaldehyde in cancer.Journal of food and drug analysis · 2024Review
- Cardiovascular Effects of Herbal Products and Their Interaction with Antihypertensive Drugs-Comprehensive Review.International journal of molecular sciences · 2024Review
- Natural Compounds and Breast Cancer: Chemo-Preventive and Therapeutic Capabilities of Chlorogenic Acid and Cinnamaldehyde.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review.Nutrients · 2022Review
- Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics.Archives of biochemistry and biophysics · 2021Article
- Modeling Pharmacokinetic Natural Product-Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach.Pharmacological reviews · 2021Review
- Use of Complementary and Alternative Medicine Among Patients With Epilepsy and Diabetes Mellitus, Focusing on the Outcome of Treatment.Frontiers in neuroscience · 2021Article
- Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions.Drug metabolism and disposition: the biological fate of chemicals · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Michael J EspirituSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.).
Justin ChenSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.).
Jaydeep YadavSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.).
Michael LarkinSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.).
Robert D PelletierSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.).
Jeannine M ChanSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.).
Jeevan B GcSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.).
Senthil NatesanSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.).
John P HarrelsonSchool of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.) harrelsonj@pacificu.edu.ORCID 0000-0002-3764-1990
Pacific University Oregon · US
Funding
Molecular biophysics of integrin activation by oxysterols and rational discovery of small-molecule modulatorsR01GM137022 · NIGMS · WASHINGTON STATE UNIVERSITY · PI NATESAN, SENTHIL KUMAR · 2020 to 2023
$1.2MSpecifics of "Non-Specific Membrane Interactions" of Drugs: An Integrated Approach for Understanding Structure-Membrane Interaction RelationshipsR15GM131293 · NIGMS · WASHINGTON STATE UNIVERSITY · PI NATESAN, SENTHIL KUMAR · 2018 to 2018
$458kNovel Tobacco Cessation AgentsR15DA042341 · NIDA · PACIFIC UNIVERSITY · PI HARRELSON, JOHN P · 2016 to 2016
$375kNIDA NIH HHS R15 DA042341NIGMS NIH HHS R01 GM137022NIGMS NIH HHS R15 GM131293
Abstract
Information is scarce regarding pharmacokinetic-based herb-drug interactions (HDI) with
Indexed as
Herb-Drug InteractionsAcroleinArea Under CurveCinnamomum zeylanicumCytochrome P-450 CYP2A6Drug Evaluation, PreclinicalHumansLetrozoleMicrosomes, LiverMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureNicotineRecombinant Proteins2-methoxycinnamaldehydeAcroleincinnamaldehydeCYP2A6 protein, humanCytochrome P-450 CYP2A6LetrozoleNicotineRecombinant Proteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT05157672ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.