ArticlePsychological medicine2021
A computational network perspective on pediatric anxiety symptoms.
Article in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Gender differences in the association between anxiety and behavioral problems in 31,400 Chinese children: a cross-sectional regression and network analysis.BMC psychiatry · 2026Article
- Transdiagnostic symptom networks in adolescent psychopathology: A longitudinal panel network analysis.JCPP advances · 2026Article
- Mapping the Relationships between Dimensions of Child Anxiety, Parental Anxiety, and Family Accommodation: A Network Analysis.Child psychiatry and human development · 2025Article
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- Multitask Learning for Mental Health: Depression, Anxiety, Stress (DAS) Using Wearables.Diagnostics (Basel, Switzerland) · 2024Article
- Networks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two U.K. Cohorts.The American journal of psychiatry · 2023Article
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans.eLife · 2022Article
- Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety.Neurobiology of stress · 2022Article
- Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders - A preliminary study.Behavioural brain research · 2021Article
- Examining the Psychometric Network Structure of Social Anxiety: A Scoping Review.Clinical psychology & psychotherapyArticle
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Authors and funding
18 authors at 11 institutions in 4 countries.
Funding
Abstract
backgroundWhile taxonomy segregates anxiety symptoms into diagnoses, patients typically present with multiple diagnoses; this poses major challenges, particularly for youth, where mixed presentation is particularly common. Anxiety comorbidity could reflect multivariate, cross-domain interactions insufficiently emphasized in current taxonomy. We utilize network analytic approaches that model these interactions by characterizing pediatric anxiety as involving distinct, inter-connected, symptom domains. Quantifying this network structure could inform views of pediatric anxiety that shape clinical practice and research.
methodsParticipants were 4964 youths (ages 5-17 years) from seven international sites. Participants completed standard symptom inventory assessing severity along distinct domains that follow pediatric anxiety diagnostic categories. We first applied network analytic tools to quantify the anxiety domain network structure. We then examined whether variation in the network structure related to age (3-year longitudinal assessments) and sex, key moderators of pediatric anxiety expression.
resultsThe anxiety network featured a highly inter-connected structure; all domains correlated positively but to varying degrees. Anxiety patients and healthy youth differed in severity but demonstrated a comparable network structure. We noted specific sex differences in the network structure; longitudinal data indicated additional structural changes during childhood. Generalized-anxiety and panic symptoms consistently emerged as central domains.
conclusionsPediatric anxiety manifests along multiple, inter-connected symptom domains. By quantifying cross-domain associations and related moderation effects, the current study might shape views on the diagnosis, treatment, and study of pediatric anxiety.
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