ArticleBMC pregnancy and childbirth2020
Perinatal and neonatal outcomes of pregnancies after early rescue intracytoplasmic sperm injection in women with primary infertility compared with conventional intracytoplasmic sperm injection: a retrospective 6-year study.
Article in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Congenital anomalies observed in children conceived through assisted reproductive technology-a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Effect of early rescue ICSI in multiple cycles of couples with successful fertilization in the initial cycle of conventional IVF.Journal of ovarian research · 2025Article
- The clinical value of short-term insemination: a retrospective analysis of 3496 patients.BMC pregnancy and childbirth · 2025Article
- Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate.Heliyon · 2024Article
- Indications affect neonatal outcomes following early rescue ICSI: a retrospective study.Journal of assisted reproduction and genetics · 2024Article
- The correlation between sperm percentage with a small acrosome and unexplained in vitro fertilization failure.BMC pregnancy and childbirth · 2024Article
- Cycle Characteristics and Pregnancy Outcomes of Early Rescue Intracytoplasmic Sperm Injection Cycles in Normal and Hyper-Ovarian Response Women: A Six-Year Retrospective Study.Journal of clinical medicine · 2023Article
- Cumulative live birth rate and neonatal outcomes after early rescue ICSI: a propensity score matching analysis.Human reproduction open · 2023Article
- Effect of early rescue ICSI and split IVF-ICSI in preventing low fertilization rate during the first ART cycle: A real-world retrospective cohort study.Reproductive medicine and biology · 2022Article
- Developmental potential of immature human oocytes aspirated after controlled ovarian stimulation.Journal of assisted reproduction and genetics · 2021Article
- Delaying Effects of Prolactin and Growth Hormone on Aging Processes in Bovine Oocytes Matured In Vitro.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Usefulness of expanding the indications of early rescue intracytoplasmic sperm injection.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEarly rescue intracytoplasmic sperm injection (ICSI) has been used in clinic as appropriate currently. While the outcomes of children born after this method were not well assessed. The purpose of this study was to evaluate the effect of early rescue ICSI on women with primary infertility.
methodsFresh embryo transfer cycles after rescue (n = 214) and conventional (n = 546) ICSI were retrospectively evaluated from women with primary infertility who underwent their first assisted reproductive technology cycles at our center in 2012-2017. The conventional ICSI group was subdivided into ICSI-1 (semen suitable for in vitro fertilization, IVF) and ICSI-2 (poor semen quality) to minimize bias from differences in semen quality. Pregnancy, delivery and neonatal outcomes were compared between groups.
resultsThere was a higher rate of polyspermy and a lower rate of top-quality embryos (TQE) on day 3 for oocytes subject to rescue ICSI compared with conventional ICSI. This reduced the total number of TQE and the number of TQE transferred in the rescue ICSI group. There was no significant difference between groups in clinical pregnancy, ongoing pregnancy, early miscarriage and live birth. For pregnant women, gestational age, route of delivery, risk of preterm birth and gestational diabetes mellitus were also comparable. Neonatal outcomes including sex ratio, birth weight, neonatal intensive care unit admission and birth defects were also similar after rescue and conventional ICSI. Moreover, no differences were observed with the different ICSI subgroups.
conclusionsFor women with primary infertility who have a high risk of IVF fertilization failure (FF), rescue ICSI provides a safe and efficient alternative to minimize FF after initial IVF, but results in fewer TQE on day 3.
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