Evidence map›Paper›PMID 32787523›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

BAF60a Deficiency in Vascular Smooth Muscle Cells Prevents Abdominal Aortic Aneurysm by Reducing Inflammation and Extracellular Matrix Degradation.

Ziyi Chang, Guizhen Zhao, Yang Zhao, Haocheng Lu, Wenhao Xiong, Wenying Liang, Jinjian Sun, Huilun Wang, Tianqing Zhu, Oren Rom and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. SMARCD1 and Its Functional Relevance in SWI/SNF and Cancer.International journal of molecular sciences · 2026
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  19. Novel pharmacological approaches in abdominal aortic aneurysm.Clinical science (London, England : 1979) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Ziyi Chang *Department of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Guizhen Zhao *Department of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Yang Zhao *Department of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Haocheng LuDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Wenhao XiongDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Wenying LiangDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Jinjian SunDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Huilun WangDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Tianqing ZhuDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Oren RomDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Yanhong GuoDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Yanbo FanDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Lin ChangDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Bo YangDepartment of Cardiac Surgery (B.Y.), University of Michigan Medical Center, Ann Arbor.
Minerva T Garcia-BarrioDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Jiandie D LinLife Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor (J.D.L.).
Y Eugene ChenDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Jifeng ZhangDepartment of Internal Medicine, Frankel Cardiovascular Center (Z.C., G.Z., Y.Z., H.L., W.X., W.L., J.S., H.W., T.Z., O.R., Y.G., Y.F., L.C., M.T.G.-B., Y.E.C., J.Z.), University of Michigan Medical Center, Ann Arbor.
Hi-Z Technology (United States) · USCentral South University · CNUniversity of Michigan · USGTx (United States) · US

Funding

Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jeffrey F Horowitz · 2010 to 2026
$20.3M
The Role of PPAR-gamma in Vascular Lesion FormationR01HL068878 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2002 to 2019
$7.6M
KLF14 and Cardiovascular DiseaseR01HL134569 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2017 to 2024
$5.3M
Kruppel-like factor 11 (KLF11) and atherosclerosisR01HL138139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, JIFENG · 2017 to 2021
$2.3M
The role of TFEB in aortic aneurysmsR01HL145176 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, YANBO · 2019 to 2022
$2.2M
Transcription Factor-EB and Postischemic AngiogenesisR01HL138094 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, YANBO · 2017 to 2021
$2.2M
Essential role of perivascular adipose tissue in blood pressure regulationR01HL122664 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHANG, LIN · 2014 to 2018
$1.9M
Mechanisms of glycine-based therapy for atherosclerosisR00HL150233 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ROM, OREN SHALOM · 2021 to 2023
$747k
Mechanisms of glycine-based therapy for atherosclerosisK99HL150233 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROM, OREN SHALOM · 2020 to 2021
$207k
NHLBI NIH HHS K99 HL150233NHLBI NIH HHS R00 HL150233NHLBI NIH HHS R01 HL068878NHLBI NIH HHS R01 HL122664NHLBI NIH HHS R01 HL134569NHLBI NIH HHS R01 HL138094NHLBI NIH HHS R01 HL138139NHLBI NIH HHS R01 HL145176NIDDK NIH HHS P30 DK089503
6 · The paper itself

Abstract

objectiveCurrently, there are no approved drugs for abdominal aortic aneurysm (AAA) treatment, likely due to limited understanding of the primary molecular mechanisms underlying AAA development and progression. BAF60a-a unique subunit of the SWI/SNF (switch/sucrose nonfermentable) chromatin remodeling complex-is a novel regulator of metabolic homeostasis, yet little is known about its function in the vasculature and pathogenesis of AAA. In this study, we sought to investigate the role and underlying mechanisms of vascular smooth muscle cell (VSMC)-specific BAF60a in AAA formation. Approach and Results: BAF60a is upregulated in human and experimental murine AAA lesions. In vivo studies revealed that VSMC-specific knockout of BAF60a protected mice from both Ang II (angiotensin II)-induced and elastase-induced AAA formation with significant suppression of vascular inflammation, monocyte infiltration, and elastin fragmentation. Through RNA sequencing and pathway analysis, we found that the expression of inflammatory response genes in cultured human aortic smooth muscle cells was significantly downregulated by small interfering RNA-mediated BAF60a knockdown while upregulated upon adenovirus-mediated BAF60a overexpression. BAF60a regulates VSMC inflammation by recruiting BRG1 (Brahma-related gene-1)-a catalytic subunit of the SWI/SNF complex-to the promoter region of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) target genes. Furthermore, loss of BAF60a in VSMCs prevented the upregulation of the proteolytic enzyme cysteine protease CTSS (cathepsin S), thus ameliorating ECM (extracellular matrix) degradation within the vascular wall in AAA.

conclusionsOur study demonstrated that BAF60a is required to recruit the SWI/SNF complex to facilitate the epigenetic regulation of VSMC inflammation, which may serve as a potential therapeutic target in preventing and treating AAA.

Indexed as

Vascular RemodelingAnimalsAorta, AbdominalAortic Aneurysm, AbdominalAortitisCase-Control StudiesCathepsinsCells, CulturedChromosomal Proteins, Non-HistoneDisease Models, AnimalExtracellular MatrixHumansInflammation MediatorsMaleMice, Inbred C57BLMice, Knockoutcathepsin SCathepsinsChromosomal Proteins, Non-HistoneInflammation MediatorsSMARCD1 protein, humanSmarcd1 protein, mouseaortic aneurysm, abdominalcathepsin Selastininflammationmonocytes

Identifiers

PMID32787523
PMCPMC7530061
OpenAlexW3049560040

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.