Evidence map›Paper›PMID 32787520›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

Loss of Down Syndrome Critical Region-1 Mediated-Hypercholesterolemia Accelerates Corneal Opacity Via Pathological Neovessel Formation.

Masashi Muramatsu, Suguru Nakagawa, Tsuyoshi Osawa, Tetsuya Toyono, Akiyoshi Uemura, Hiroyasu Kidoya, Nobuyuki Takakura, Tomohiko Usui, Sandra Ryeom, Takashi Minami

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Down syndrome: a review of ocular manifestations.Therapeutic advances in ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 3 countries.

Masashi Muramatsu *Division of Molecular and Vascular Biology, IRDA, Kumamoto University, Japan (M.M., T.M.).
Suguru Nakagawa *Division of Genome Science (S.N.), RCAST, the University of Tokyo, Japan.
Tsuyoshi Osawa *Integrative Nutriomics (T.O.), RCAST, the University of Tokyo, Japan.
Tetsuya ToyonoDepartment Ophthalmology, Graduate School of Medicine, the University of Tokyo, Japan (S.N., T.T., T.U.).
Akiyoshi UemuraDepartment Retinal Vascular Biology, Nagoya City University Graduate School of Medical Sciences, Japan (A.U.).
Hiroyasu KidoyaDepartment Signal Transduction, RIMD, Osaka University, Japan (H.K., N.T.).
Nobuyuki TakakuraDepartment Signal Transduction, RIMD, Osaka University, Japan (H.K., N.T.).
Tomohiko UsuiDepartment Ophthalmology, Graduate School of Medicine, the University of Tokyo, Japan (S.N., T.T., T.U.).
Sandra RyeomDepartment Cancer Biology, University of Pennsylvania (S.R.).
Takashi MinamiDivision of Molecular and Vascular Biology, IRDA, Kumamoto University, Japan (M.M., T.M.).
Twitter (United States) · USCenter for Genomic Science · ITHamamatsu University · JPIntegrative Medicine Institute · USKumamoto University Hospital · JPNagoya City University · JPOsaka University of Pharmaceutical Sciences · JPThe University of Tokyo · JPTokyo University of Information Sciences · JP

Funding

Negative Regulation of VEGF-Mediated AngiogenesisR01CA118374 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RYEOM, SANDRA · 2009 to 2019
$3.4M
NCI NIH HHS R01 CA118374
6 · The paper itself

Abstract

objectiveThe calcineurin-NFAT (nuclear factor for activated T cells)-DSCR (Down syndrome critical region)-1 pathway plays a crucial role as the downstream effector of VEGF (vascular endothelial growth factor)-mediated tumor angiogenesis in endothelial cells. A role for DSCR-1 in different organ microenvironment such as the cornea and its role in ocular diseases is not well understood. Corneal changes can be indicators of various disease states and are easily detected through ocular examinations. Approach and Results: The presentation of a corneal arcus or a corneal opacity due to lipid deposition in the cornea often indicates hyperlipidemia and in most cases, hypercholesterolemia. Although the loss of Apo (apolipoprotein) E has been well characterized and is known to lead to elevated serum cholesterol levels, there are few corneal changes observed in

conclusionsThis study is the first demonstration of the critical role for the endogenous inhibitor of calcineurin, DSCR-1, and pathological corneal angiogenesis in hypercholesterolemia induced corneal opacity.

Indexed as

AnimalsCalcium-Binding ProteinsChemokine CXCL12Chemotaxis, LeukocyteCorneal NeovascularizationCorneal OpacityDisease Models, AnimalDisease ProgressionDNA-Binding ProteinsEndothelial CellsEndothelium, CornealEye Infections, FungalHEK293 CellsHumansHypercholesterolemiaLymphangiogenesisCalcium-Binding ProteinsChemokine CXCL12Cxcl12 protein, mouseCXCR4 protein, mouseDNA-Binding ProteinsDSCR1 protein, mouseMuscle ProteinsRCAN1 protein, humanReceptors, CXCR4Vascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseangiogenesiscalcineurincorneal opacitydown syndromehyaluronan receptorhypercholesterolemialymphangiogenesis

Identifiers

PMID32787520
PMCPMC7518298
OpenAlexW3049062424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.