Observational studyCirculation. Cardiovascular imaging2020
Greater Neurobiological Resilience to Chronic Socioeconomic or Environmental Stressors Associates With Lower Risk for Cardiovascular Disease Events.
Observational study in Circulation. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- Imaging Findings Associated With Socioenvironmental Exposures Inform Mechanisms of Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Age modulates the link between stress-related neural activity and mortality.Nature communications · 2025Article
- Relation between resting amygdala activity and cardiovascular events in patients with cardiac sarcoidosis.European journal of nuclear medicine and molecular imaging · 2025Article
- Brain health: a new concept to the neurologist - an initiative of the Lifestyle Medicine Commission of the Brazilian Academy of Neurology.Arquivos de neuro-psiquiatria · 2025Review
- Stress-related genetic factors modify the effect of socioeconomic status on cardiovascular risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Stress drives myelopoiesis to impair atherosclerosis resolution.Research square · 2025Article
- The Science of Tai Chi andJournal of integrative and complementary medicine · 2025Review
- Article
- Urban environmental noise and depression causal pathway: Potential role of chronic conditions as mediator.PloS one · 2025Article
- Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024Review
- Imaging of the brain-heart axis: prognostic value in a European setting.European heart journal · 2024Article
- Association of transportation noise with cardiovascular diseases.Clinical cardiology · 2024Review
- Personal Strategies to Reduce the Cardiovascular Impacts of Environmental Exposures.Circulation research · 2024Review
- The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort.Frontiers in psychiatry · 2024Article
- Artificial Intelligence Empowered Nuclear Medicine and Molecular Imaging in Cardiology: A State-of-the-Art Review.Phenomics (Cham, Switzerland) · 2023Review
- Associations between long-term aircraft noise exposure, cardiovascular disease, and mortality in US cohorts of female nurses.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Noise and Air Pollution as Risk Factors for Hypertension: Part II-Pathophysiologic Insight.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Aircraft noise exposure induces pro-inflammatory vascular conditioning and amplifies vascular dysfunction and impairment of cardiac function after myocardial infarction.Cardiovascular research · 2023Article
- A Pilot Study of Neurobiological Mechanisms of Stress and Cardiovascular Risk.Medical research archives · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChronic exposure to socioeconomic or environmental stressors associates with greater stress-related neurobiological activity (ie, higher amygdalar activity [AmygA]) and higher risk of major adverse cardiovascular events (MACE). However, among individuals exposed to such stressors, it is unknown whether neurobiological resilience (NBResilience, defined as lower AmygA despite stress exposure) lowers MACE risk. We tested the hypotheses that NBResilience protects against MACE, and that it does so through decreased bone marrow activity and arterial inflammation.
methodsIndividuals underwent
resultsOf 254 individuals studied (median age [interquartile range]: 57 years [46-67], 36.7% male), 166 were exposed to at least one chronic stressor. Among stress-exposed individuals, 12 experienced MACE over a median follow-up of 3.75 years. Among this group, higher AmygA (ie, lower resilience) associated with higher bone marrow activity (standardized β [95% CI]: 0.192 [0.030-0.353],
conclusionsAmong individuals who are chronically exposed to socioeconomic or environmental stressors, NBResilience (AmygA <1 SD above the mean) associates with a >50% reduction in MACE risk, potentially via reduced arterial inflammation. These data raise the possibility that enhancing NBResilience may decrease the burden of cardiovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.