ArticleJournal of the American Chemical Society2020
Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Building Molecules by a Self-Replicator That Catalyzes Acyl Hydrazone Formation.Angewandte Chemie (International ed. in English) · 2026Article
- Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy.Journal of the American Chemical Society · 2025Article
- Article
- Molecular-level insights into the supramolecular gelation mechanism of urea derivative.Nature communications · 2025Article
- Competitive exclusion among self-replicating molecules curtails the tendency of chemistry to diversify.Nature chemistry · 2025Article
- Review
- In Operando Imaging Electrostatic-Driven Disassembly and Reassembly of Collagen Nanostructures.ACS nano · 2024Article
- Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism.Nature microbiology · 2024Article
- Artificial cell synthesis using biocatalytic polymerization-induced self-assembly.Nature chemistry · 2024Article
- Light-driven eco-evolutionary dynamics in a synthetic replicator system.Nature chemistry · 2024Article
- Watching Molecular Nanotubes Self-Assemble in Real Time.Journal of the American Chemical Society · 2023Article
- Kinetic Modeling and Parameter Estimation of a Prebiotic Peptide Reaction Network.Journal of molecular evolution · 2023Article
- Reactive Martini: Chemical Reactions in Coarse-Grained Molecular Dynamics Simulations.Journal of chemical theory and computation · 2023Article
- A new antibiotic from an uncultured bacterium binds to an immutable target.bioRxiv : the preprint server for biology · 2023Article
- Spatiotemporal resolution in high-speed atomic force microscopy for studying biological macromolecules in action.Microscopy (Oxford, England) · 2023Review
- Selection of diverse polymorphic structures from a small dynamic molecular network controlled by the environment.Chemical science · 2022Article
- Article
- Modelling structural properties of cyanine dye nanotubes at coarse-grained level.Nanoscale advances · 2022Article
- Supramolecular systems chemistry through advanced analytical techniques.Analytical and bioanalytical chemistry · 2022Review
- Stochastic Emergence of Two Distinct Self-Replicators from a Dynamic Combinatorial Library.Journal of the American Chemical Society · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-assembly features prominently in fields ranging from materials science to biophysical chemistry. Assembly pathways, often passing through transient intermediates, can control the outcome of assembly processes. Yet, the mechanisms of self-assembly remain largely obscure due to a lack of experimental tools for probing these pathways at the molecular level. Here, the self-assembly of self-replicators into fibers is visualized in real-time by high-speed atomic force microscopy (HS-AFM). Fiber growth requires the conversion of precursor molecules into six-membered macrocycles, which constitute the fibers. HS-AFM experiments, supported by molecular dynamics simulations, revealed that aggregates of precursor molecules accumulate at the sides of the fibers, which then diffuse to the fiber ends where growth takes place. This mechanism of precursor reservoir formation, followed by one-dimensional diffusion, which guides the precursor molecules to the sites of growth, reduces the entropic penalty associated with colocalizing precursors and growth sites and constitutes a new mechanism for supramolecular polymerization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.