Evidence map›Paper›PMID 32786412›Full record

ArticleBiochemistry2020

Structural Analysis of Binding Determinants of

Christine M Harvey, Katherine H O'Toole, Chunliang Liu, Patrick Mariano, Debra Dunaway-Mariano, Karen N Allen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christine M HarveyDepartment of Chemistry, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-2474-8350
Katherine H O'TooleDepartment of Chemistry, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0001-6180-7607
Chunliang LiuDepartment of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Patrick MarianoDepartment of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Debra Dunaway-MarianoDepartment of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID 0000-0001-6045-1207
Karen N AllenDepartment of Chemistry, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0001-7296-0551
Boston University · USUniversity of New Mexico · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI MALCOLM S. CAPEL · 2018 to 2026
$34.2M
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Life Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Trehalose-6-phosphate phosphatase inhibitors as anti-helminthicsR21AI127623 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI ALLEN, KAREN N. · 2017 to 2018
$512k
Trehalose-6-phosphate phosphatase: a target for anti-onchocerciasis therapeuticsR21AI103484 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI ALLEN, KAREN N., DUNAWAY-MARIANO, DEBRA · 2013 to 2014
$451k
NIAID NIH HHS R21 AI103484NIAID NIH HHS R21 AI127623NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P41 GM103393NIGMS NIH HHS P41 GM111244NIH HHS S10 OD021527
6 · The paper itself

Abstract

Trehalose-6-phosphate phosphatase (T6PP) catalyzes the dephosphorylation of trehalose 6-phosphate (T6P) to the disaccharide trehalose. The enzyme is not present in mammals but is essential to the viability of multiple lower organisms as trehalose is a critical metabolite, and T6P accumulation is toxic. Hence, T6PP is a target for therapeutics of human pathologies caused by bacteria, fungi, and parasitic nematodes. Here, we report the X-ray crystal structures of

Indexed as

Binding SitesCrystallography, X-RayLigandsModels, MolecularPhosphoric Monoester HydrolasesProtein BindingProtein FoldingProtein Structure, QuaternarySalmonella typhimuriumSubstrate SpecificitySugar PhosphatesTrehaloseLigandsPhosphoric Monoester HydrolasesSugar PhosphatesTrehalosetrehalose-6-phosphatetrehalose-phosphatase

Identifiers

PMID32786412
PMCPMC10251262
OpenAlexW3046962793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.