Evidence map›Paper›PMID 32786303›Full record

ArticleACS chemical neuroscience2020

A Pentacyclic Triterpene from

Wenjie Luo, Fanny C F Ip, Guangmiao Fu, Kit Cheung, Yuan Tian, Yueqing Hu, Anjana Sinha, Elaine Y L Cheng, Xianzhong Wu, Victor Bustos and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Wenjie LuoLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Fanny C F IpDivision of Life Science, State Key Laboratory of Molecular Neuroscience, and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong, China.ORCID 0000-0001-5162-1761
Guangmiao FuDivision of Life Science, State Key Laboratory of Molecular Neuroscience, and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong, China.
Kit CheungDivision of Life Science, State Key Laboratory of Molecular Neuroscience, and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong, China.ORCID 0000-0002-4572-5414
Yuan TianLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Yueqing HuDivision of Life Science, State Key Laboratory of Molecular Neuroscience, and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong, China.
Anjana SinhaLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Elaine Y L ChengDivision of Life Science, State Key Laboratory of Molecular Neuroscience, and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong, China.
Xianzhong WuChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Victor BustosLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Paul GreengardLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Yue-Ming LiChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID 0000-0002-2633-3730
Subhash C SinhaLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.ORCID 0000-0001-8916-5677
Nancy Y IpDivision of Life Science, State Key Laboratory of Molecular Neuroscience, and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong, China.ORCID 0000-0002-2763-8907
Hong Kong University of Science and Technology · HKRockefeller University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Regulation of y-secretase activity by modulatory proteinsR01AG061350 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2019 to 2023
$4.3M
Substrate Feedback Mechanism of gamma-SecretaseRF1AG057593 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2018 to 2018
$2.1M
Mechanism and Synergy of gamma-Secretase ModulatorsR01NS096275 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2016 to 2020
$2.1M
NCI NIH HHS P30 CA008748NIA NIH HHS R01 AG061350NIA NIH HHS RF1 AG057593NINDS NIH HHS R01 NS096275
6 · The paper itself

Abstract

Amyloid-beta peptides generated by β-secretase- and γ-secretase-mediated successive cleavage of amyloid precursor protein are believed to play a causative role in Alzheimer's disease. Thus, reducing amyloid-beta generation by modulating γ-secretase remains a promising approach for Alzheimer's disease therapeutic development. Here, we screened fruit extracts of

Indexed as

Alzheimer DiseaseLigustrumAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsMicePentacyclic TriterpenesAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesPentacyclic TriterpenesAlzheimer’s diseaseamyloid precursor proteinbeta-amyloidoleanolic acidsecretasesynaptic plasticity

Identifiers

PMID32786303
PMCPMC8325170
OpenAlexW3048741897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.