ArticleACS chemical biology2020
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.
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Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
–field-weighted citation impact
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Who cites it
12 citing papers in PubMed.
- Molecular dynamics simulations of intrinsically disordered protein regions enable biophysical interpretation of variant-effect predictors.HGG advances · 2026Article
- Mutational Scanning of α-Synuclein using a Clickable Protein Tag Reveals Determinants of Membrane-Induced Aggregation.bioRxiv : the preprint server for biology · 2026Article
- Concentration-dependent mutational scanning probes the cellular folding landscape of α-synuclein in yeast.Protein science : a publication of the Protein Society · 2026Article
- Concentration-Dependent Mutational Scanning Probes the Cellular Folding Landscape of α-Synuclein in Yeast.bioRxiv : the preprint server for biology · 2025Article
- From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae.Yeast (Chichester, England) · 2025Review
- Scalable approaches for generating, validating and incorporating data from high-throughput functional assays to improve clinical variant classification.Human genetics · 2024Article
- Enhancing efficiency of protein language models with minimal wet-lab data through few-shot learning.Nature communications · 2024Article
- ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction.bioRxiv : the preprint server for biology · 2023Article
- Integrating deep mutational scanning and low-throughput mutagenesis data to predict the impact of amino acid variants.GigaScience · 2022Article
- Plasticity of Membrane Binding by the Central Region of α-Synuclein.Frontiers in molecular biosciences · 2022Article
- Spiers Memorial Lecture: Analysis andFaraday discussions · 2021Article
- Review
Corrections and comments
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Authors and funding
46 authors.
Robert W NewberryDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.ORCID 0000-0002-2020-2641
Taylor ArharChemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States.
Jean CostelloIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
George C HartoularosIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Alison M MaxwellChemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States.
Zun Zar Chi NaingIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Maureen PittmanIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Nishith R ReddyIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Daniel M C SchwarzChemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States.
Douglas R WassarmanChemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States.
Taia S WuChemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States.
Daniel BarreroIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Christa CaggianoIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Adam CatchingIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Taylor B CavazosIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Laurel S EstesIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Bryan FaustIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Elissa A FinkIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Miriam A GoldmanIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Yessica K GomezIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
M Grace GordonIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Laura M GunsalusIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Nick HoppeIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Maru Jaime-GarzaIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Matthew C JohnsonIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Matthew G JonesIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Andrew F KungIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Kyle E LopezIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Jared LumpeIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Calla MartynIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Elizabeth E McCarthyIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Lakshmi E Miller-VedamIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Erik J NavarroIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Aji PalarIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Jenna PellegrinoIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Wren SaylorIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Christina A StephensIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Jack StricklandIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Hayarpi TorosyanIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Stephanie A WankowiczIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Daniel R WongIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Garrett WongIntegrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States.
Sy ReddingDepartment of Biochemistry and Biophysics, University of California, San Francisco, California 94143, United States.
Eric D ChowDepartment of Biochemistry and Biophysics, University of California, San Francisco, California 94143, United States.
William F DeGradoDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.
Martin KampmannDepartment of Biochemistry and Biophysics, University of California, San Francisco, California 94143, United States.ORCID 0000-0002-3819-7019
Funding
VIRAL DEGENERATIVE DEMENTING DISEASE IN AGING (SUPP)P01AG002132 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHNIER, PAUL · 1985 to 2024
$51.7MMaximizing Opportunities for Research Excellence - Evaluation Training SupplementR25GM056847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUNCAN, D'ANNE S., SELLO, JASON K · 1998 to 2023
$14.1MMOLECULAR AND CELLULAR BASIS OF CARDIOVASCULAR DISEASET32HL007731 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 1992 to 2026
$12.4MUsing Networks to Seed Hierarchical Whole-cell Models of CancerU54CA209891 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI IDEKER, TREY · 2017 to 2021
$10.9MSTRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1MRESEARCH TRAINING IN CHEMISTRY AND CHEMICAL BIOLOGYT32GM064337 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIK, CHARLES SCOTT · 2002 to 2021
$7.8MDeciphering the relationship between structure, dynamics and function in helical bundle proteinsR35GM122603 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILLIAM DEGRADO · 2017 to 2026
$7.1MBMI Bioinformatics Training GrantsT32GM067547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2003 to 2022
$6.6MIntegrative Program in Complex Biological System (ipCBS)T32EB009383 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSHALL, WALLACE, WEINER, ORION D · 2009 to 2022
$3.2MRewiring of the human protein homeostasis network in normal and disease contextsDP2GM119139 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN · 2015 to 2015
$2.3MA Multiscale Model of Protein Mediated Changes in membrane MorphologyR01GM117593 · NIGMS · COLORADO STATE UNIVERSITY · PI ZHOU, YONGCHENG · 2015 to 2019
$1.8MUtilizing single-cell Massively Parallel Reporter Assays to dissect gene by environment interactionsF31HG011007 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORDON, MARY GRACE · 2020 to 2022
$117kNCI NIH HHS F31 CA232325NCI NIH HHS F31 CA243439NCI NIH HHS U54 CA209891NHGRI NIH HHS F31 HG011007NHLBI NIH HHS T32 HL007731NIA NIH HHS P01 AG002132NIBIB NIH HHS T32 EB009383NIGMS NIH HHS DP2 GM119139NIGMS NIH HHS R01 GM117593NIGMS NIH HHS R25 GM056847NIGMS NIH HHS R35 GM122603NIGMS NIH HHS T32 GM008284NIGMS NIH HHS T32 GM064337NIGMS NIH HHS T32 GM067547
Abstract
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins
Indexed as
alpha-SynucleinAmino Acid SequenceHumansMutationParkinson DiseaseProtein ConformationSaccharomyces cerevisiaealpha-Synuclein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.